Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | TOP1 | P11387 | 3/20 | 0.32 |
| ▸ | GRM5 | P41594 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 5/20 | 0.32 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.32 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.32 |
| ▸ | DHODH | Q02127 | 2/20 | 0.31 |
| ▸ | MST1R | Q04912 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004795 | 0.84 | FGFR2 (0.36) | MAPK14NPC1TOP1METDHODH | |
| SCHEMBL6004849 | 0.80 | MET (0.45) | METMST1R | |
| SCHEMBL6004327 | 0.79 | TOP1 (0.42) | MAPK14NPC1TOP1PDGFRBPDGFRA | |
| SCHEMBL6004276 | 0.79 | LMNA (0.39) | NPC1TOP1PDGFRBPDGFRADHODH | |
| SCHEMBL6005302 | 0.79 | DHODH (0.39) | MAPK14TOP1DHODH | |
| SCHEMBL6004171 | 0.78 | NPC1 (0.33) | NPC1METPDGFRBPDGFRADHODH | |
| SCHEMBL6004093 | 0.78 | MET (0.45) | METPDGFRBPDGFRAMST1R | |
| SCHEMBL6004803 | 0.76 | FGFR2 (0.36) | NPC1PDGFRBPDGFRADHODH | |
| SCHEMBL6005342 | 0.76 | MET (0.42) | NPC1TOP1METPDGFRBPDGFRA | |
| SCHEMBL6002787 | 0.76 | CCNC (0.39) | MAPK14NPC1DHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |