Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR2 | Q16832 | 1/20 | 0.34 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | BTK | Q06187 | 2/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 6/20 | 0.33 |
| ▸ | AXL | P30530 | 5/20 | 0.33 |
| ▸ | KDR | P35968 | 4/20 | 0.33 |
| ▸ | TEK | Q02763 | 2/20 | 0.32 |
| ▸ | FLT4 | P35916 | 1/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | MERTK | Q12866 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005366 | 0.91 | PDGFRB (0.36) | DDR2PDGFRBPDGFRAFGFR2SRC | |
| SCHEMBL6004922 | 0.87 | SLC22A12 (0.39) | DDR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6005251 | 0.86 | PDE2A (0.39) | DDR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004162 | 0.83 | ALDH1A1 (0.36) | DDR2PDGFRBPDGFRAFGFR2SRC | |
| SCHEMBL6004262 | 0.83 | ALDH1A1 (0.36) | DDR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004285 | 0.82 | CYP3A4 (0.46) | — | |
| SCHEMBL6004343 | 0.81 | SIGMAR1 (0.36) | DDR2PDGFRBPDGFRAFGFR2BTK | |
| SCHEMBL6004146 | 0.80 | SRC (0.38) | PDGFRBPDGFRASRCTGFBR1KDR | |
| SCHEMBL6004932 | 0.80 | IRAK4 (0.39) | — | |
| SCHEMBL6004333 | 0.79 | PDGFRA (0.42) | PDGFRBPDGFRATGFBR1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |