Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | YES1 | P07947 | 1/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.33 |
| ▸ | PPARD | Q03181 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004932 | 0.88 | IRAK4 (0.39) | KITFLT3 | |
| SCHEMBL6004162 | 0.86 | ALDH1A1 (0.36) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6004262 | 0.84 | ALDH1A1 (0.36) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6004922 | 0.84 | SLC22A12 (0.39) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6005251 | 0.83 | PDE2A (0.39) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6005366 | 0.82 | PDGFRB (0.36) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6004251 | 0.80 | TGFBR1 (0.39) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6005281 | 0.79 | DDR2 (0.34) | PDGFRATGFBR1PDGFRBAXL | |
| SCHEMBL6004285 | 0.79 | CYP3A4 (0.46) | HPGDALOX5 | |
| SCHEMBL6004825 | 0.79 | SLC6A2 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |