Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 10/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTSA | P10619 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17357044 | 0.79 | HMGCR (0.37) | HMGCRPOLBCTSAACHE | |
| SCHEMBL17359393 | 0.79 | HMGCR (0.37) | HMGCRPOLBCTSAACHEKDM4E | |
| SCHEMBL5324634 | 0.79 | GABRP (0.43) | HMGCRPOLB | |
| SCHEMBL5327876 | 0.78 | FOLH1 (0.42) | HMGCRPOLBCTSAACHESLC22A6 | |
| SCHEMBL14796398 | 0.77 | LMNA (0.37) | SLC22A6TDP1 | |
| SCHEMBL8385734 | 0.76 | ALDH1A1 (0.44) | SLC22A6TDP1 | |
| SCHEMBL8382256 | 0.76 | ALDH1A1 (0.42) | HMGCRPOLBCTSAACHETDP1 | |
| SCHEMBL10880225 | 0.75 | POLB (0.35) | POLBCTSAACHEKDM4E | |
| SCHEMBL7990050 | 0.75 | CYP2D6 (0.38) | HMGCRPOLBCTSAACHEKDM4E | |
| SCHEMBL3313487 | 0.74 | POLB (0.43) | HMGCRPOLBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239886-B1 | LABELLED ASCORBIC ACID DERIVATIVES | GE HEALTHCARE LTD (GB) | 2006-11-29 | — | — | EP | disclosed |
| US-6749832-B2 | DIAGNOSIS, PROGNOSIS AND RADIOTHERAPY OF METASTATIC BONE DISEASE; SUCH AS TAGGED 5-(2-AMINO-1-HYDROXYETHYL)-3,4-DIBENZYLOXY-5H-FURAN-2-ONE | AMERSHAM PLC (GB) | 2004-06-15 | — | — | US | disclosed |
| US-20030153736-A1 | Labelled ascorbic acid derivatives | GE HEALTHCARE LIMITED (GB) | 2003-08-14 | — | — | US | disclosed |
| EP-1239886-A2 | LABELLED ASCORBIC ACID DERIVATIVES | GE Healthcare Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001047564-A2 | LABELLED ASCORBIC ACID DERIVATIVES | AMERSHAM PLC (GB) | 2001-07-05 | — | — | WO | disclosed |
| US-5962438-A | OSTEOPOROSIS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1999-10-05 | — | — | US | disclosed |
| EP-0827951-A1 | NOVEL BONE-SEEKING ESTROGEN DERIVATIVE | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1998-03-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030153736-A1 | Labelled ascorbic acid derivatives | CYP27B1, CYP24A1, XDH | HMGCR 240/4885POLB 2675/4885CTSA 947/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.