Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12615990 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KMT2A | |
| SCHEMBL4817068 | 0.71 | THRB (0.38) | ALPLKDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL11427034 | 0.70 | ALPL (0.36) | ALPLKDM4EALDH1A1HSD17B10KMT2A | |
| SCHEMBL5119375 | 0.67 | ALOX5 (0.44) | ALDH1A1KMT2A | |
| Tetrazole SCHEMBL28199209 | 0.66 | PNMT (0.35) | PGR | |
| SCHEMBL1250423 | 0.66 | KDM4E (0.42) | ALPLKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7212332 | 0.66 | PTGES (0.44) | — | |
| SCHEMBL9014087 | 0.66 | IDO1 (0.30) | — | |
| SCHEMBL1200471 | 0.66 | NOTUM (0.42) | — | |
| SCHEMBL5813250 | 0.66 | P2RX7 (0.39) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1471915-A4 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS INC (US) | 2006-02-15 | — | — | EP | disclosed |
| EP-1471915-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | Rigel Pharmaceuticals, Inc. (US) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003063794-A2 | 2,4-PYRIMIDINEDIAMINE COMPOUNDS AND THEIR USES | RIGEL PHARMACEUTICALS, INC. (US) | 2003-08-07 | — | — | WO | disclosed |