SCHEMBL6017882

SCHEMBL6017882

Nc1ccc(C(=O)c2ccc3cc(S(=O)(=O)O)c(N)c(O)c3c2)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NT5E P21589 2/20 0.41
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA9 Q16790 2/20 0.40
CA12 O43570 1/20 0.40
CA14 Q9ULX7 1/20 0.40
CASP6 P55212 3/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
ALDH1A1 P00352 3/20 0.37
HSD17B10 Q99714 2/20 0.37
CASP1 P29466 1/20 0.37
CASP7 P55210 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
IGFBP3 P17936 1/20 0.36
NSD2 O96028 1/20 0.35
DUSP3 P51452 1/20 0.35
PTPN5 P54829 1/20 0.35
PTPN11 Q06124 1/20 0.35
RAPGEF4 Q8WZA2 1/20 0.35
MEN1 O00255 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6018444 0.90 CASP6 (0.43) NT5ECA1CA2CA9CA12
SCHEMBL7790474 0.84 NT5E (0.57) NT5ECASP6CTDSP1ALDH1A1HSD17B10
SCHEMBL10014029 0.76 CASP6 (0.55) NT5ECASP6CTDSP1ALDH1A1HSD17B10
SCHEMBL16454269 0.75 ALDH1A1 (0.42) NT5ECASP6ALDH1A1HSD17B10TDP1
SCHEMBL10259579 0.74 CDC25B (0.50) NT5ECA1CA2CA9CA12
SCHEMBL5694580 0.72 CTRB1 (0.48) CASP6ALDH1A1TDP1MEN1KMT2A
SCHEMBL14339180 0.72 ALDH1A1 (0.38) NT5ECA2CASP6ALDH1A1HSD17B10
SCHEMBL8958777 0.72 POLB (0.47) NT5ECA1CA2CA9CA12
SCHEMBL14495157 0.71 ENPP2 (0.48) NT5ECA1CA2CA9CA12
SCHEMBL10579215 0.71 KMT2A (0.43) NT5ECA1CA2CA9CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7066969-B2 Dyes incorporating annionic and cationic groups CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-06-27 US disclosed
US-20040205912-A1 Dyes incorporating annionic and cationic groups CIBA SPECIALTY CHEMICALS CORP. 2004-10-21 US disclosed
EP-1442082-A1 DYES INCORPORATING ANIONIC AND CATIONIC GROUPS Ciba SC Holding AG (CH) 2004-08-04 EP disclosed
WO-2003010239-A1 DYES INCORPORATING ANIONIC AND CATIONIC GROUPS CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-02-06 WO disclosed