Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2451886 | 0.90 | ALDH1A1 (0.41) | ALDH1A1ALOX15TSHRTRPA1 | |
| Ethylene Glycol SCHEMBL1885267 | 0.87 | MAPT (0.34) | ALDH1A1TSHRMAPTHSD17B10 | |
| SCHEMBL23165889 | 0.83 | — | — | |
| SCHEMBL1638639 | 0.82 | MAPT (0.34) | TSHRMAPTHSD17B10 | |
| SCHEMBL10707670 | 0.82 | MAPT (0.34) | TSHRMAPTHSD17B10 | |
| SCHEMBL10707675 | 0.82 | MAPT (0.34) | TSHRMAPTHSD17B10 | |
| SCHEMBL596042 | 0.82 | MAPT (0.34) | TSHRMAPTHSD17B10 | |
| Di(Hydroxyethyl)Ether SCHEMBL1887097 | 0.81 | TSHR (0.48) | ALDH1A1TSHRMAPTHSD17B10 | |
| SCHEMBL2843100 | 0.80 | TSHR (0.42) | TSHRHSD17B10 | |
| SCHEMBL24202437 | 0.80 | LMNA (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7135491-B2 | 5-Aryltetrazole compounds and uses thereof | INOTEK PHARMACEUTICALS CORP. (US) | 2006-11-14 | — | — | US | disclosed |
| US-7087631-B2 | Aryltetrazole compounds, and compositions thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2006-08-08 | — | — | US | disclosed |
| US-20060135519-A2 | 5-ARYLTETRAZOLE COMPOUNDS AND COMPOSITIONS THEREOF | NIVOROZHKIN ALEXANDER | 2006-06-22 | — | — | US | disclosed |
| US-20050159418-A1 | 5-Aryltetrazoles compounds and compositions thereof | NIVOROZHKIN ALEX (US) | 2005-07-21 | — | — | US | disclosed |
| US-20050159467-A1 | 5-Aryltetrazole compounds and uses thereof | NIVOROZHKIN ALEX (US) | 2005-07-21 | — | — | US | disclosed |
| EP-1542980-A1 | 5-ARYLTETRAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND USES THEREFOR | Inotek Pharmaceuticals Corporation (US) | 2005-06-22 | — | — | EP | disclosed |
| US-20040116423-A1 | 5-Aryltetrazole compounds, compositions thereof, and uses therefor | INOTEK PHARMACEUTICALS CORPORATION | 2004-06-17 | — | — | US | disclosed |
| WO-2004009563-A1 | 5-ARYLTETRAZOLE COMPOUNDS, COMPOSITIONS THEREOF, AND USES THEREFOR | INOTEK PHARMACEUTICALS CORPORATION (US) | 2004-01-29 | — | — | WO | disclosed |
| EP-0441932-A1 | FLUOROBENZOLE DERIVATIVES AND MESOMORPHOUS MEDIUM. | MERCK PATENT GMBH (DE) | 1991-08-21 | — | — | EP | disclosed |
| EP-0431402-A2 | Di- and trifluormethoxy compounds and their use as components of a liquid crystal medium | MERCK PATENT GmbH (DE) | 1991-06-12 | — | — | EP | disclosed |
| WO-1991003450-A1 | FLUOROBENZOLE DERIVATIVES AND MESOMORPHOUS MEDIUM | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-03-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135519-A2 | 5-ARYLTETRAZOLE COMPOUNDS AND COMPOSITIONS THEREOF | CASP5, NOX5, IL5 | ALDH1A1 271/4885ALOX15 33/4885TSHR 2774/4885 |
| US-20050159467-A1 | 5-Aryltetrazole compounds and uses thereof | NLRP3, XDH, CASP5 | ALDH1A1 234/4885ALOX15 71/4885TSHR 2226/4885 |
| US-20050159418-A1 | 5-Aryltetrazoles compounds and compositions thereof | NLRP3, CASP5, CASP3 | ALDH1A1 281/4885ALOX15 37/4885TSHR 2648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.