SCHEMBL6034824 — predicted protein targets

Known targets — ChEMBL curated mechanism

GABBR1 GABBR2 GABRA1 GABRA2 GABRA3 GABRA4 GABRA5 GABRA6 GABRB1 GABRB2 GABRB3 GABRD GABRE GABRG1 GABRG2 GABRG3 GABRP GABRQ GRIN1 GRIN2A GRIN2B GRIN2C GRIN2D GRIN3A GRIN3B HMGCR MMP1 MMP13 MMP7 MMP8 PTGS1 PTGS2 ileS pol rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	PPARG	P37231	2/20	0.34

▸	FFAR1	O14842	2/20	0.33

▸	TRPA1	O75762	2/20	0.33

▸	SLC16A3	O15427	2/20	0.33

▸	SLC16A1	P53985	2/20	0.33

▸	TRPV1	Q8NER1	1/20	0.32

▸	DGAT1	O75907	2/20	0.32

▸	CYP1A2	P05177	1/20	0.32

▸	CYP3A4	P08684	1/20	0.32

▸	CYP2D6	P10635	1/20	0.32

▸	CYP2C19	P33261	1/20	0.32

▸	GAA	P10253	1/20	0.32

▸	KDM4E	B2RXH2	1/20	0.32

▸	LMNA	P02545	1/20	0.32

▸	MAPT	P10636	1/20	0.32

▸	SIRT2	Q8IXJ6	1/20	0.31

▸	ALDH1A1	P00352	1/20	0.31

▸	HSD11B1	P28845	1/20	0.31

▸	PPARD	Q03181	1/20	0.31

▸	PPARA	Q07869	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL6034828	0.91	PPARG (0.41)	PPARGFFAR1TRPA1SLC16A3SLC16A1
SCHEMBL6034648	0.91	DGAT1 (0.35)	PPARGSLC16A3SLC16A1DGAT1CYP1A2
SCHEMBL6035703	0.85	DGAT1 (0.37)	PPARGTRPA1DGAT1PPARDPPARA
SCHEMBL6034475	0.85	DGAT1 (0.40)	PPARGDGAT1GAAKDM4ELMNA
SCHEMBL6035774	0.83	AURKA (0.35)	PPARGSLC16A3SLC16A1KDM4EALDH1A1
SCHEMBL6035144	0.82	PPARG (0.35)	PPARGSLC16A3SLC16A1KDM4EALDH1A1
SCHEMBL6034655	0.82	PPARG (0.40)	PPARGSLC16A3SLC16A1DGAT1PPARD
SCHEMBL6034583	0.81	SMN1; SMN2 (0.39)	PPARGDGAT1KDM4ELMNAMAPT
SCHEMBL6035708	0.77	PPARA (0.43)	PPARGDGAT1PPARDPPARA
SCHEMBL6035651	0.77	ALDH1A1 (0.38)	PPARGSLC16A3SLC16A1DGAT1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20060148858-A1	1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity	TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP)	2006-07-06	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20060148858-A1	1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity	GPR119, SLC5A1, CYP4B1	PPARG 1037/4885FFAR1 376/4885TRPA1 2893/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.