Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | GRN | P28799 | 1/20 | 0.33 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2827976 | 0.81 | LMNA (0.46) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL17473347 | 0.79 | KDM4E (0.35) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL27848637 | 0.79 | GABRA5 (0.40) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL28752471 | 0.78 | SMYD3 (0.40) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL14642681 | 0.75 | — | — | |
| SCHEMBL17653923 | 0.75 | PKM (0.43) | KDM4EHSD17B10ALDH1A1PTGS2PTGS1 | |
| SCHEMBL28804198 | 0.74 | HTT (0.42) | ALDH1A1LMNAGAAMEN1KMT2A | |
| SCHEMBL17796523 | 0.73 | CTSB (0.45) | KDM4EHPGDHSD17B10ALDH1A1MAPT | |
| SCHEMBL23403192 | 0.72 | GPR84 (0.32) | MEN1KMT2A | |
| SCHEMBL23399240 | 0.71 | GABRA1 (0.32) | KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103189370-B | Triazole derivatives as ligands for GABA receptors | HOFFMANN LA ROCHE | 2015-07-08 | — | — | CN | disclosed |
| CN-102414205-B | Isoxazole-pyrazole derivatives | HOFFMANN LA ROCHE | 2014-11-05 | — | — | CN | disclosed |
| CN-103189370-A | Triazole derivatives as ligands for GABA receptors | HOFFMANN LA ROCHE | 2013-07-03 | — | — | CN | disclosed |
| CN-102414205-A | Isoxazole-pyrazole derivatives | HOFFMANN LA ROCHE | 2012-04-11 | — | — | CN | disclosed |
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148858-A1 | 1, 2-Azole derivatives with hypoglycemic and hypolipidemic activity | GPR119, SLC5A1, CYP4B1 | KDM4E 509/4885HPGD 3297/4885HSD17B10 204/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.