SCHEMBL60475

SCHEMBL60475

[CH2]c1ccc(OC)cc1OC(=O)OCC1c2ccccc2-c2ccccc21

nearest known ligand 0.45

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ FABP5 Q01469 3/20 0.45
▸ EPHX2 P34913 1/20 0.40
▸ KMT2A Q03164 3/20 0.39
▸ TSHR P16473 2/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ GPR55 Q9Y2T6 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ FABP7 O15540 2/20 0.39
▸ KLK7 P49862 1/20 0.39
▸ GAA P10253 1/20 0.38
▸ MAPT P10636 1/20 0.38
▸ KDM4E B2RXH2 1/20 0.38
▸ ALDH1A1 P00352 1/20 0.38
▸ RAB9A P51151 1/20 0.37
▸ MDM2 Q00987 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6135377 0.89 FABP5 (0.39) FABP5EPHX2KMT2ATSHRHTT
SCHEMBL9225108 0.77 GAA (0.49) FABP5EPHX2KMT2AMEN1HTT
SCHEMBL9225114 0.76 FABP5 (0.44) FABP5EPHX2KMT2AMEN1FABP7
SCHEMBL29400602 0.75 FABP5 (0.39) FABP5KMT2ATSHRMEN1HTT
SCHEMBL27575610 0.75 FABP5 (0.46) FABP5EPHX2KMT2ATSHRMEN1
SCHEMBL27143076 0.74 FABP5 (0.52) FABP5EPHX2KMT2AFABP7
SCHEMBL15119354 0.74 KMT2A (0.60) FABP5EPHX2KMT2AFABP7
SCHEMBL5188476 0.73 RAB9A (0.40) KMT2ATSHRMEN1HTTGAA
SCHEMBL44676 0.73 KMT2A (0.58) FABP5EPHX2KMT2AFABP7
SCHEMBL14099780 0.73 CYP1A2 (0.47) FABP5EPHX2KMT2AFABP7GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 194 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110945017-B Bifunctional compounds 诺和诺德股份有限公司 2024-07-16 — — CN disclosed
US-20240000803-A1 ORAL FORMULATION OF BIOLOGICALLY ACTIVE MATERIAL CONJUGATE HAVING BIOTIN MOIETY, FATTY ACID MOIETY, OR COMBINATION THEREOF COUPLED THERETO D&D PHARMATECH INC. (KR) 2024-01-04 — — US disclosed
CN-116940384-A Oral formulations having bioactive material conjugates coupled to biotin moieties, fatty acid moieties, or combinations thereof D&D制药技术股份有限公司 2023-10-24 — — CN disclosed
CN-116916965-A Bioactive material conjugates with conjugated biotin moieties, fatty acid moieties, or combinations thereof D&D制药技术股份有限公司 2023-10-20 — — CN disclosed
EP-4252780-A1 BIOLOGICALLY ACTIVE MATERIAL CONJUGATE HAVING BIOTIN MOIETY, FATTY ACID MOIETY, OR COMBINATION THEREOF COUPLED THERETO D&D Pharmatech Inc. (KR) 2023-10-04 — — EP disclosed
EP-4252781-A1 ORAL FORMULATION OF BIOLOGICALLY ACTIVE MATERIAL CONJUGATE HAVING BIOTIN MOIETY, FATTY ACID MOIETY, OR COMBINATION THEREOF COUPLED THERETO D&D Pharmatech Inc. (KR) 2023-10-04 — — EP disclosed
US-11572398-B2 GLP-1 derivatives and uses thereof NOVO NORDISK A/S (DK) 2023-02-07 — — US disclosed
US-20230000834-A1 PHYSIOLOGICALLY ACTIVE SUBSTANCE BOUND TO BIOTIN MOIETY, AND COMPOSITION FOR ORAL ADMINISTRATION INCLUDING SAME D&D PHARMATECH, INC. (KP) 2023-01-05 — — US disclosed
US-11518795-B2 Double-acylated GLP-1 derivatives NOVO NORDISK A/S (DK) 2022-12-06 — — US disclosed
CN-108699126-B GLP-1 derivatives and uses thereof 诺和诺德股份有限公司 2022-12-06 — — CN disclosed
WO-2006097537-A2 ACYLATED GLP-1 COMPOUNDS NOVO NORDISK A/S (DK) 2006-09-21 — — WO disclosed
WO-2006097538-A1 EXTENDED GLP-1 COMPOUNDS NOVO NORDISK A/S (DK) 2006-09-21 — — WO disclosed
EP-1434599-A4 HUMAN 3 RELAXIN FLOREY HOWARD INST (AU) 2006-09-20 — — EP disclosed
US-20060135434-A1 New peptides GE HEALTHCARE AS (NO) 2006-06-22 — — US disclosed
US-20060089307-A1 Peptides that bind to the heparin binding domian of vegf and vegfr-2 GE HEALTHCARE AS (NO) 2006-04-27 — — US disclosed
EP-1578785-A1 PEPTIDES THAT BIND TO THE HEPARIN BINDING DOMAIN OF VEGF AND VEGFR-2 Amersham Health AS (NO) 2005-09-28 — — EP disclosed
US-20050026822-A1 Human 3 relaxin ASTRAZENECA AB (SE) 2005-02-03 — — US disclosed
WO-2004058802-A1 PEPTIDES THAT BIND TO THE HEPARIN BINDING DOMIAN OF VEGF AND VEGFR-2 AMERSHAM HEALTH AS (NO) 2004-07-15 — — WO disclosed
EP-1434599-A1 HUMAN 3 RELAXIN HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) 2004-07-07 — — EP disclosed
WO-2003030930-A1 HUMAN 3 RELAXIN HOWARD FLOREY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE (AU) 2003-04-17 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060135434-A1 New peptides FLT4, FLT1, KDR FABP5 734/4885EPHX2 3704/4885KMT2A 4457/4885
US-20240000803-A1 ORAL FORMULATION OF BIOLOGICALLY ACTIVE MATERIAL CONJUGATE HAVING BIOTIN MOIETY, FATTY ACID MOIETY, OR COMBINATION THEREOF COUPLED THERETO FABP2, FABP1, ALOX15B FABP5 16/4885EPHX2 255/4885KMT2A 4144/4885
US-20060089307-A1 Peptides that bind to the heparin binding domian of vegf and vegfr-2 KDR, FLT1, FLT4 FABP5 439/4885EPHX2 3981/4885KMT2A 4553/4885
US-20230000834-A1 PHYSIOLOGICALLY ACTIVE SUBSTANCE BOUND TO BIOTIN MOIETY, AND COMPOSITION FOR ORAL ADMINISTRATION INCLUDING SAME BTD, FABP2, PLPBP FABP5 62/4885EPHX2 719/4885KMT2A 3868/4885
US-11572398-B2 GLP-1 derivatives and uses thereof GLP1R, GIPR, GCG FABP5 382/4885EPHX2 1828/4885KMT2A 4053/4885
US-11518795-B2 Double-acylated GLP-1 derivatives GLP1R, GIPR, GPR119 FABP5 944/4885EPHX2 1351/4885KMT2A 313/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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