Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 15/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP12 | P39900 | 1/20 | 0.35 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.35 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4350616 | 0.94 | KIF11 (0.41) | KIF11MMP1MMP2MMP9MMP12 | |
| SCHEMBL9878919 | 0.84 | KIF11 (0.40) | KIF11MMP1MMP2MMP9MMP12 | |
| SCHEMBL2009145 | 0.81 | MMP1 (0.41) | KIF11MMP1MMP2MMP9MMP12 | |
| SCHEMBL28535887 | 0.81 | KIF11 (0.36) | KIF11MMP1MMP2MMP9MMP12 | |
| SCHEMBL5680233 | 0.79 | ALPI (0.51) | SLC1A3SLC1A2SLC1A1PKM | |
| SCHEMBL2403306 | 0.78 | SLC7A5 (0.51) | SLC1A3SLC1A2SLC1A1CYP1A2CYP2D6 | |
| SCHEMBL14227031 | 0.78 | ATM (0.44) | KIF11SLC1A3PKMIDO1 | |
| SCHEMBL14150614 | 0.78 | ATM (0.44) | KIF11SLC1A3PKMIDO1 | |
| SCHEMBL14150613 | 0.78 | ATM (0.44) | KIF11SLC1A3PKMIDO1 | |
| SCHEMBL58410 | 0.77 | MMP2 (0.40) | KIF11MMP1MMP2MMP9MMP12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074900-B2 | Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-07-11 | — | — | US | disclosed |
| US-6838113-B1 | Increasing the digestibility of food proteins by thioredoxin reduction | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2005-01-04 | — | — | US | disclosed |
| US-20040091578-A1 | Stabilization of hypoallergenic, hyperdigestible previously reduced proteins | THE REGENTS OF UNIVERSITY OF CALIFORNIA | 2004-05-13 | — | — | US | disclosed |
| US-20040071738-A1 | Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin | BUCHANAN BOB B (US) | 2004-04-15 | — | — | US | disclosed |
| US-6677433-B2 | PROTEINS ARE REDUCED WITH THIOL REDOX PROTEINS AND FURTHER REACTED WITH CYSTAMINE OR OXIDIZED GLUTATHIONE TO PREVENT REOXIDATION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2004-01-13 | — | — | US | disclosed |
| US-20030215542-A1 | Use of thiol redox proteins for reducing protein intramolecular disulfide bonds, for improving the quality of cereal products, dough and baked goods and for inactivating snake, bee and scorpion toxins | BUCHANAN BOB B (US) | 2003-11-20 | — | — | US | disclosed |
| US-6610334-B1 | Reducing cystine containing animal and plant proteins, and improving dough and baked goods' characteristics is provided which includes the steps of mixing dough ingredients with a thiol redox protein to form a dough and baking the dough to | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-08-26 | — | — | US | disclosed |
| US-6600021-B1 | Enzyme inhibitor for use in the preparation of dough and baked goods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-07-29 | — | — | US | disclosed |
| US-6583271-B1 | Reduction of amylase inhibitor proteins in sample; obtain thioredoxin, reduce prsence, monitor adjustment in enzyme activity in sample | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-06-24 | — | — | US | disclosed |
| US-6555116-B1 | Hypo-allergenic pollen protein that has been treated with thioredoxin, nicotinamide adenine dinucleotide phosphate-thioredoxin reductase (NTR) and reduced nicotinamide adenine dinucleotide phosphate (NADPH). | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-04-29 | — | — | US | disclosed |
| US-5952034-A | FOOD TREATMENT WITH THIOREDOXIN, NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE-THIOREDOXIN REDUCTASE, REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE (NADPH)AND ADMINISTERING TREATED FOOD TO ANIMAL | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-09-14 | — | — | US | disclosed |
| WO-1999020122-A1 | INCREASING THE DIGESTIBILITY OF FOOD PROTEINS BY THIOREDOXIN REDUCTION | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-04-29 | — | — | WO | disclosed |
| EP-0672127-B1 | USE OF THIOL REDOX PROTEINS FOR REDUCING DISULFIDE BONDS | UNIV CALIFORNIA (US) | 1999-01-07 | — | — | EP | disclosed |
| EP-0863154-A1 | Use of thiol redox proteins for reducing protein intramolecular disulfide bonds, for improving the quality of cereal products, dough and baked goods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-09-09 | — | — | EP | disclosed |
| US-5792506-A | DISULFIDE BONDS ARE REDUCED TO SULFHYDRYL DECREASING ALLERGENICITY OF FEEDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0784676-A1 | NEUTRALIZATION OF FOOF ALLERGENS BY THIOREDOXIN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-23 | — | — | EP | disclosed |
| WO-1996012799-A1 | NEUTRALIZATION OF FOOF ALLERGENS BY THIOREDOXIN | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-05-02 | — | — | WO | disclosed |
| EP-0672127-A4 | USE OF THIOL REDOX PROTEINS FOR REDUCING DISULFIDE BONDS. | UNIV CALIFORNIA (US) | 1996-03-27 | — | — | EP | disclosed |
| EP-0672127-A1 | USE OF THIOL REDOX PROTEINS FOR REDUCING DISULFIDE BONDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-09-20 | — | — | EP | disclosed |
| WO-1993008274-A1 | USE OF THIOL REDOX PROTEINS FOR REDUCING DISULFIDE BONDS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1993-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040071738-A1 | Alleviation of the allergenic potential of airborne and contact allergens by thioredoxin | TXNRD1, TXN2, TXNRD3 | KIF11 4416/4885MMP1 186/4885MMP2 835/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.