SCHEMBL6063233

SCHEMBL6063233

O=C(O)NC[C@@H](SCc1ccccc1)C(=O)NCC(O)(CCc1ccccc1)c1nc2ccccc2o1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
FAAH O00519 1/20 0.37
CES1 P23141 1/20 0.37
DAGLA Q9Y4D2 1/20 0.37
MAPT P10636 5/20 0.36
LMNA P02545 3/20 0.36
CYP1A2 P05177 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
HPGD P15428 2/20 0.35
GFER P55789 1/20 0.35
TSHR P16473 3/20 0.35
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
SMN1; SMN2 Q16637 2/20 0.35
MAPK1 P28482 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
CYP3A4 P08684 1/20 0.34
KMT2A Q03164 5/20 0.33
MEN1 O00255 4/20 0.33
XDH P47989 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6462136 1.00 FAAH (0.37) FAAHCES1DAGLAMAPTLMNA
SCHEMBL6468283 0.89 L3MBTL1 (0.32) FAAHCES1DAGLAMAPTLMNA
SCHEMBL6467288 0.89 NPSR1 (0.38) FAAHCES1DAGLAMAPTLMNA
SCHEMBL7042868 0.85 MAPT (0.36) FAAHCES1DAGLAMAPTLMNA
SCHEMBL6462741 0.83 FAAH (0.36) FAAHCES1DAGLAMAPTLMNA
SCHEMBL6467037 0.81 FAAH (0.36) FAAHCES1DAGLAMAPTLMNA
SCHEMBL6466282 0.80 LMNA (0.39) FAAHCES1DAGLAMAPTLMNA
SCHEMBL6463256 0.80 CTSS (0.38) LMNATSHRCYP3A4KMT2AMEN1
SCHEMBL6063199 0.80 RAB9A (0.35) NPC1RAB9ACYP3A4KMT2A
SCHEMBL7049306 0.78 DAGLA (0.44) FAAHCES1DAGLAMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1694357-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2006-08-30 EP disclosed
WO-2005058348-A1 USE OF CATHEPSIN S INHIBITORS FOR TREATING AN IMMUNE RESPONSE CAUSED BY ADMINISTRATION OF A SMALL MOLECULE THERAPEUTIC OR BIOLOGIC AXYS PHARMACEUTICALS, INC. (US) 2005-06-30 WO disclosed