Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | RAB9A | P51151 | 3/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23191916 | 0.87 | TDP1 (0.58) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL29754225 | 0.87 | ALDH1A1 (0.48) | MAPTRAB9ASMN1; SMN2ALDH1A1LOXL2 | |
| SCHEMBL1421363 | 0.87 | ALDH1A1 (0.48) | MAPTRAB9ASMN1; SMN2ALDH1A1LOXL2 | |
| SCHEMBL9953733 | 0.82 | RAB9A (0.53) | MAPTRAB9ASMN1; SMN2ALDH1A1LOXL2 | |
| SCHEMBL5558418 | 0.80 | CYP4F2 (0.49) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL6669062 | 0.80 | RAB9A (0.75) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL21171359 | 0.77 | MAPT (0.76) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL27337757 | 0.76 | KMT2A (0.69) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8066511 | 0.76 | TDP1 (0.59) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL2364505 | 0.75 | LOXL2 (0.59) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7122565-B2 | Thiadiazoles and oxadiazoles and their use as phosphodiesterase-7 inhibitors | WARNER-LAMBERT LLC (US) | 2006-10-17 | — | — | US | disclosed |