Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPFFR2 | Q9Y5X5 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | UNG | P13051 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | PYGL | P06737 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6077672 | 0.77 | L3MBTL1 (0.43) | KMT2AL3MBTL1MEN1MAPTTDP1 | |
| SCHEMBL6076759 | 0.76 | ALDH1A1 (0.51) | L3MBTL1ALDH1A1MAPTTDP1NPC1 | |
| SCHEMBL6873224 | 0.73 | G6PC1 (0.56) | KMT2ANPFFR2NPSR1L3MBTL1MEN1 | |
| SCHEMBL12757027 | 0.72 | SRC (0.56) | KMT2ANPFFR2NPSR1MEN1G6PC1 | |
| SCHEMBL7237460 | 0.67 | KDM4E (0.61) | KMT2AL3MBTL1MEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL6865973 | 0.67 | GPR55 (0.41) | KMT2ANPFFR2NPSR1MEN1ALDH1A1 | |
| SCHEMBL6865977 | 0.67 | GPR55 (0.41) | KMT2ANPFFR2NPSR1MEN1ALDH1A1 | |
| SCHEMBL8462042 | 0.67 | NPFFR2 (0.60) | KMT2ANPFFR2NPSR1MEN1G6PC1 | |
| SCHEMBL6877540 | 0.66 | PLA2G7 (0.41) | KMT2AL3MBTL1MEN1MAPTTDP1 | |
| SCHEMBL2164853 | 0.65 | KMT2A (0.58) | KMT2ANPFFR2NPSR1L3MBTL1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7109186-B2 | 4-hydroxy-5-oxo-1-(2-[4-methylpiperazin-1-yl]ethyl)-2,5-dihydro-1H-pyrrole-3-carboxylic acid (3,4-dichlorobenzyl)-methyl-amide for human immunodeficiency virus (HIV) treatment | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-09-19 | — | — | US | disclosed |
| US-20040110804-A1 | HIV integrase inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2004-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040110804-A1 | HIV integrase inhibitors | CDKN1A, SAMHD1, CTCF | KMT2A 736/4885NPFFR2 4665/4885NPSR1 4603/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.