Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JUN | P05412 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.57 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.54 |
| ▸ | TFEB | P19484 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.52 |
| ▸ | BACE1 | P56817 | 3/20 | 0.50 |
| ▸ | GSK3B | P49841 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | FOS | P01100 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL608597 | 1.00 | JUN (0.57) | JUNNFKB1NFE2L2TFEBHDAC1 | |
| SCHEMBL16815421 | 0.84 | KDM4E (0.57) | JUNNFKB1NFE2L2TFEBBACE1 | |
| SCHEMBL16815420 | 0.84 | KDM4E (0.57) | JUNNFKB1NFE2L2TFEBBACE1 | |
| SCHEMBL10061367 | 0.84 | MMP9 (0.52) | HDAC1HDAC2HDAC8BACE1GSK3B | |
| SCHEMBL609603 | 0.83 | NFE2L2 (0.78) | NFE2L2TFEBBACE1GSK3BAR | |
| SCHEMBL609604 | 0.83 | NFE2L2 (0.78) | NFE2L2TFEBBACE1GSK3BAR | |
| SCHEMBL20586439 | 0.82 | NFE2L2 (0.55) | JUNNFKB1NFE2L2TFEBHDAC1 | |
| SCHEMBL7689317 | 0.81 | KDM4E (0.68) | JUNNFKB1NFE2L2TFEBBACE1 | |
| SCHEMBL7689315 | 0.81 | KDM4E (0.68) | JUNNFKB1NFE2L2TFEBBACE1 | |
| SCHEMBL9907017 | 0.78 | GSK3B (0.53) | JUNNFE2L2BACE1GSK3BFOS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090263492-A1 | Diagnostic Methods and Genetic Markers for Alzheimer Disease | HUMAN BIOMOLECULAR RESEARCH INSTITUTE | 2009-10-22 | — | — | US | claimed |
| WO-2008048410-A9 | DIAGNOSTIC METHODS AND GENETIC MARKERS FOR ALZHEIMER DISEASE | HUMAN BIOMOLECULAR RES INST (US) | 2008-06-26 | — | — | WO | claimed |
| WO-2008048410-A2 | DIAGNOSTIC METHODS AND GENETIC MARKERS FOR ALZHEIMER DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2008-04-24 | — | — | WO | claimed |
| US-11596716-B2 | Compounds and matrices for use in bone growth and repair | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2023-03-07 | — | — | US | disclosed |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2021-05-13 | — | — | US | disclosed |
| US-10874766-B2 | Compounds and matrices for use in bone growth and repair | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2020-12-29 | — | — | US | disclosed |
| EP-3038621-B1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RES INSTITUTE (US) | 2020-12-02 | — | — | EP | disclosed |
| US-20160038641-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2016-02-11 | — | — | US | disclosed |
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-02-16 | — | — | US | disclosed |
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2012-02-16 | — | — | US | disclosed |
| WO-2010068935-A2 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2010-06-17 | — | — | WO | disclosed |
| US-20090263492-A1 | Diagnostic Methods and Genetic Markers for Alzheimer Disease | HUMAN BIOMOLECULAR RESEARCH INSTITUTE | 2009-10-22 | — | — | US | disclosed |
| WO-2008048410-A9 | DIAGNOSTIC METHODS AND GENETIC MARKERS FOR ALZHEIMER DISEASE | HUMAN BIOMOLECULAR RES INST (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008048410-A2 | DIAGNOSTIC METHODS AND GENETIC MARKERS FOR ALZHEIMER DISEASE | HUMAN BIOMOLECULAR RESEARCH INSTITUTE (US) | 2008-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10874766-B2 | Compounds and matrices for use in bone growth and repair | BMP2, BMP4, BMP6 | JUN 2257/4885NFKB1 1057/4885NFE2L2 1522/4885 |
| US-11596716-B2 | Compounds and matrices for use in bone growth and repair | BMP2, BMP4, BMP6 | JUN 1770/4885NFKB1 1137/4885NFE2L2 1181/4885 |
| US-20090263492-A1 | Diagnostic Methods and Genetic Markers for Alzheimer Disease | CHAT, SLC18A3, GAP43 | JUN 4432/4885NFKB1 3594/4885NFE2L2 2656/4885 |
| US-20210138117-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | BMP2, BMP4, BMP6 | JUN 1770/4885NFKB1 1137/4885NFE2L2 1181/4885 |
| US-20160038641-A1 | COMPOUNDS AND MATRICES FOR USE IN BONE GROWTH AND REPAIR | BMP2, BMP4, BMP6 | JUN 2775/4885NFKB1 1635/4885NFE2L2 1486/4885 |
| US-20120040976-A1 | SMALL MOLECULE IMMUNOMODULATORS FOR ALZHEIMER'S DISEASE | L1CAM, LY96, GMFG | JUN 4222/4885NFKB1 800/4885NFE2L2 2405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.