Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC26A4 | O43511 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6090266 | 0.85 | SLC26A4 (0.46) | SLC26A4NR4A2NPC1RAB9APTGER4 | |
| SCHEMBL6088697 | 0.85 | PTGDR2 (0.46) | SLC26A4NR4A2NPC1RAB9APTGER4 | |
| SCHEMBL6089761 | 0.85 | GPR132 (0.49) | SLC26A4NR4A2NPC1RAB9APTGER4 | |
| SCHEMBL6088674 | 0.83 | SLC26A4 (0.63) | SLC26A4KMT2AMEN1NR4A2NPC1 | |
| SCHEMBL4450809 | 0.80 | NR4A2 (0.58) | SLC26A4KMT2AMEN1NR4A2PTGER4 | |
| SCHEMBL6088483 | 0.78 | SLC26A4 (0.52) | SLC26A4KMT2AMEN1NR4A2NPC1 | |
| SCHEMBL6089332 | 0.78 | NR4A2 (0.67) | SLC26A4KMT2AMEN1NR4A2NPC1 | |
| SCHEMBL6090532 | 0.78 | SLC26A4 (0.51) | SLC26A4KMT2AMEN1NR4A2NPC1 | |
| SCHEMBL4451992 | 0.78 | SLC26A4 (0.53) | SLC26A4KMT2AMEN1NR4A2NPC1 | |
| SCHEMBL6090535 | 0.77 | NPC1 (0.55) | SLC26A4KMT2AMEN1NR4A2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |