Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.44 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | MRGPRX4 | Q96LA9 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087884 | 0.90 | ABCB1 (0.45) | GPR132MEN1ALDH1A1KMT2AABCB1 | |
| SCHEMBL6089761 | 0.89 | GPR132 (0.49) | GPR132SLC26A4ABCB1HTR1ADRD2 | |
| SCHEMBL6089840 | 0.84 | CYSLTR1 (0.59) | — | |
| SCHEMBL6090266 | 0.83 | SLC26A4 (0.46) | GPR132ALDH1A1SLC26A4PTGER4NR4A2 | |
| SCHEMBL4450809 | 0.80 | NR4A2 (0.58) | MEN1ALDH1A1KMT2ASLC26A4MAOB | |
| SCHEMBL6091367 | 0.80 | FFAR1 (0.53) | SLC26A4PTGER4NR4A2FFAR1MRGPRX4 | |
| SCHEMBL6088989 | 0.80 | CYSLTR1 (0.61) | — | |
| SCHEMBL6088689 | 0.78 | NPC1 (0.46) | GPR132ALDH1A1ABCB1HTR1ADRD2 | |
| SCHEMBL6088674 | 0.78 | SLC26A4 (0.63) | MEN1KMT2ASLC26A4MAOBPTGER4 | |
| SCHEMBL6089251 | 0.77 | SLC26A4 (0.49) | MEN1KMT2ASLC26A4MAOBPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| CN-1183113-C | Tri-aryl acid derivatives as PPAR receptor ligands | ���ĵ�˹ҩ��¹�����˾ | 2005-01-05 | — | — | CN | disclosed |
| CN-1356983-A | Tri-aryl acid derivatives as PPAR receptor ligands | AVENTIS PHARM PROD INC (DE) | 2002-07-03 | — | — | CN | disclosed |