Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | UBE2M | P61081 | 1/20 | 0.42 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MBOAT4 | Q96T53 | 3/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ENPP1 | P22413 | 3/20 | 0.39 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15063412 | 0.82 | GAA (0.47) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL7433052 | 0.79 | KDM1A (0.44) | KDM1AALDH1A1MAPK1LMNACYP1A2 | |
| SCHEMBL5983773 | 0.79 | KDM1A (0.44) | KDM1AALDH1A1MAPK1LMNACYP1A2 | |
| SCHEMBL609785 | 0.77 | ALDH1A1 (0.67) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL5096009 | 0.76 | EGLN2 (0.50) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL4241122 | 0.75 | MEN1 (0.36) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL3230229 | 0.74 | HPGD (0.45) | ALDH1A1MAPK1LMNACYP1A2NPSR1 | |
| SCHEMBL30419680 | 0.74 | UBE2M (0.49) | KDM1AALDH1A1MAPK1LMNACYP1A2 | |
| SCHEMBL4263342 | 0.73 | KDM4E (0.46) | KDM1AALDH1A1MAPK1LMNACYP1A2 | |
| SCHEMBL10887539 | 0.73 | ALDH1A1 (0.43) | ALDH1A1MAPK1LMNACYP1A2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021113266-A1 | TREATING COGNITIVE DISORDERS USING TRAPIDIL | SINOPIA BIOSCIENCES, INC. (US) | 2021-06-10 | — | — | WO | disclosed |
| US-8557828-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBVIE INC. (US) | 2013-10-15 | — | — | US | disclosed |
| EP-2500347-A1 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | Abbott Laboratories (US) | 2012-09-19 | — | — | EP | disclosed |
| EP-2142552-B1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LAB (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120041003-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2012-02-16 | — | — | US | disclosed |
| US-8076344-B2 | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LABORATORIES (US) | 2011-12-13 | — | — | US | disclosed |
| EP-2142552-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | Abbott Laboratories (US) | 2010-01-13 | — | — | EP | disclosed |
| US-20080293713-A1 | Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme | ABBOTT LABORATORIES (US) | 2008-11-27 | — | — | US | disclosed |
| WO-2008134690-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | ABBOTT LABORATORIES (US) | 2008-11-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120041003-A1 | INHIBITORS OF DIACYLGLYCEROL O-ACYLTRANSFERASE TYPE 1 ENZYME | DGAT1, DGAT2, LCAT | KDM1A 1397/4885ALDH1A1 220/4885MAPK1 1247/4885 |
| US-20080293713-A1 | Inhibitors of Diacylglycerol O-acyltransferase Type 1 Enzyme | DGAT1, DGAT2, LCAT | KDM1A 1397/4885ALDH1A1 220/4885MAPK1 1247/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.