Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 6/20 | 0.48 |
| ▸ | DRD2 | P14416 | 4/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095635 | 0.84 | ALDH1A1 (0.47) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6098260 | 0.83 | TSHR (0.40) | TDP1ALDH1A1SMN1; SMN2NPSR1KDM4E | |
| SCHEMBL6099900 | 0.83 | HTR7 (0.35) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL18852692 | 0.79 | PSIP1 (0.48) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6097428 | 0.79 | KEAP1 (0.39) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL27645438 | 0.78 | HTR7 (0.44) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6095322 | 0.78 | HSD11B1 (0.44) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL6097857 | 0.77 | MMP1 (0.44) | HSD11B1HTR6POLBSMN1; SMN2KDM4E | |
| SCHEMBL13703524 | 0.75 | PSIP1 (0.52) | HTR7DRD2HTR1AHTR2AHTR1B | |
| SCHEMBL7296391 | 0.75 | PSIP1 (0.46) | HTR7DRD2HTR1AHTR2AHTR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | HTR7 1/4885DRD2 74/4885HTR1A 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.