Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9001396 | 0.79 | HTT (0.36) | EP300HTTMAPTALOX15HBB | |
| SCHEMBL9001403 | 0.78 | CES1 (0.39) | EP300HTTMAPTALOX15HBB | |
| SCHEMBL9149341 | 0.78 | SMN1; SMN2 (0.35) | EP300HTTMAPTALOX15HBB | |
| SCHEMBL28825178 | 0.77 | HTT (0.33) | EP300HTTMAPTALOX15HBB | |
| SCHEMBL9001399 | 0.74 | CES1 (0.34) | EP300HTTMAPTALOX15HBB | |
| SCHEMBL8547645 | 0.74 | L3MBTL1 (0.38) | HTTMAPTALOX15HBBCES1 | |
| SCHEMBL28494258 | 0.73 | EPHX1 (0.34) | HTTMAPTALOX15HBBCES1 | |
| SCHEMBL8205168 | 0.69 | ALDH1A1 (0.40) | L3MBTL1KMT2A | |
| SCHEMBL4262537 | 0.68 | MAPT (0.33) | EP300HTTMAPTALOX15HBB | |
| SCHEMBL28386645 | 0.67 | ALDH1A1 (0.34) | EP300HTTMAPTALOX15HBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101260077-A | Quinolin-2-ones derivative, pharmaceutical composition and use thereof | KUNMING INST BOTANY CN ACAD (CN) | 2008-09-10 | — | — | CN | claimed |
| CN-114853582-A | Method for preparing aryl ketone through green continuous photochemical rearrangement | 姚昕辰 | 2022-08-05 | — | — | CN | disclosed |
| CN-101260077-B | Quinolin-2-ones derivative, pharmaceutical composition and use thereof | KUNMING INST BOTANY CN ACAD | 2011-06-15 | — | — | CN | disclosed |
| CN-101260077-A | Quinolin-2-ones derivative, pharmaceutical composition and use thereof | KUNMING INST BOTANY CN ACAD (CN) | 2008-09-10 | — | — | CN | disclosed |
| US-7087641-B2 | 4β-1″-[(2″-substituted benzoyl) anilino]podophyllotoxin analogues useful as anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2006-08-08 | — | — | US | disclosed |
| EP-1377588-B1 | 4-BETA-1''-[(2''-(SUBSTITUTED BENZOYL)ANILINO] PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL SCIENT IND RES (IN) | 2005-08-10 | — | — | EP | disclosed |
| US-20050101804-A1 | 4Beta-1\"-{2'-substituted benzoyl) anilino] podophyllotoxin analogues useful as anticancer agents | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2005-05-12 | — | — | US | disclosed |
| EP-1377588-A1 | 4-BETA-1''-[(2''-(SUBSTITUTED BENZOYL)ANILINO] PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2004-01-07 | — | — | EP | disclosed |
| WO-2003082876-A1 | 4-BETA-1''-`(2''-(SUBSTITUTED BENZOYL)ANILINO! PODOPHYLLOTOXIN ANALOGUES USEFUL AS ANTICANCER AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2003-10-09 | — | — | WO | disclosed |
| EP-0918773-A1 | PROCESS FOR THE PRODUCTION OF 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO 1,5-A]BENZODIAZEPINE | PHARMACIA & UPJOHN COMPANY (US) | 1999-06-02 | — | — | EP | disclosed |
| WO-1998000427-A1 | PROCESS FOR THE PRODUCTION OF 8-CHLORO-6-(2-FLUOROPHENYL)-1-METHYL-4H-IMIDAZO[1,5-A]BENZODIAZEPINE | PHARMACIA & UPJOHN COMPANY (US) | 1998-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050101804-A1 | 4Beta-1\"-{2'-substituted benzoyl) anilino] podophyllotoxin analogues useful as anticancer agents | TUBB4A, CASP4, TUBB4B | EP300 4801/4885HTT 3598/4885MAPT 3491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.