Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6101719 | 0.73 | EP300 (0.33) | EPHX1MEN1KMT2ANPC1HTT | |
| SCHEMBL28825178 | 0.68 | HTT (0.33) | EPHX1MEN1KMT2ANPC1HTT | |
| SCHEMBL10894162 | 0.65 | HTT (0.36) | MEN1KMT2APABPC1CCR6ATM | |
| SCHEMBL8547645 | 0.65 | L3MBTL1 (0.38) | EPHX1MEN1KMT2ANPC1HTT | |
| SCHEMBL7430909 | 0.62 | CES1 (0.38) | EPHX1HTTMAPTALOX15HBB | |
| SCHEMBL6510160 | 0.62 | MAPT (0.38) | EPHX1MEN1KMT2AHTTMAPT | |
| SCHEMBL993045 | 0.60 | CES1 (0.45) | EPHX1MEN1KMT2AHTTMAPT | |
| SCHEMBL528381 | 0.60 | MAPT (0.40) | EPHX1MEN1KMT2ANPC1HTT | |
| SCHEMBL4959086 | 0.59 | CES1 (0.39) | EPHX1MEN1KMT2AHTTMAPT | |
| SCHEMBL4035521 | 0.59 | ALDH1A1 (0.39) | EPHX1MEN1KMT2AHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112062768-B | Micromolecule with Aurora kinase degradation activity and preparation method and application thereof | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2021-08-31 | — | — | CN | disclosed |
| CN-112062768-A | Micromolecule with Aurora kinase degradation activity and preparation method and application thereof | 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） | 2020-12-11 | — | — | CN | disclosed |