Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 5/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 5/20 | 0.40 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25988418 | 0.87 | GAA (0.49) | POLBSMN1; SMN2ALDH1A1GAAL3MBTL1 | |
| SCHEMBL21983967 | 0.85 | POLB (0.47) | POLBSMN1; SMN2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL3190074 | 0.83 | POLB (0.49) | POLBSMN1; SMN2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL13851204 | 0.83 | POLB (0.46) | POLBSMN1; SMN2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL15195867 | 0.81 | POLB (0.50) | POLBSMN1; SMN2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL10896219 | 0.80 | STS (0.37) | ALDH1A1KDM4EFBP1 | |
| SCHEMBL2073262 | 0.80 | PIK3CG (0.57) | POLBSMN1; SMN2ALDH1A1ELANEGAA | |
| SCHEMBL14508206 | 0.80 | ELANE (0.39) | POLBALDH1A1ELANEL3MBTL1LMNA | |
| SCHEMBL1655934 | 0.77 | POLB (0.55) | POLBSMN1; SMN2ALDH1A1TAS1R3TAS1R1 | |
| SCHEMBL15355870 | 0.76 | S1PR3 (0.44) | ALDH1A1ELANEMAPTKDM4EFBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12391680-B2 | Compounds and compositions for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2025-08-19 | — | — | US | disclosed |
| US-9944603-B2 | Compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2018-04-17 | — | — | US | disclosed |
| US-9944603-B2 | Compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2018-04-17 | — | — | US | disclosed |
| US-9944603-B2 | Compounds and methods for the treatment of cystic fibrosis | FLATLEY DISCOVERY LAB, LLC (US) | 2018-04-17 | — | — | US | disclosed |
| US-20170313659-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2017-11-02 | — | — | US | disclosed |
| US-20170313659-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2017-11-02 | — | — | US | disclosed |
| US-20170313659-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB LLC (US) | 2017-11-02 | — | — | US | disclosed |
| EP-2968285-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | Flatley Discovery Lab (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20140371238-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140371238-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | FLATLEY DISCOVERY LAB (US) | 2014-12-18 | — | — | US | disclosed |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100041020-A1 | Methods for detecting the presence, location or quantity of targets using novel dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041020-A1 | Methods for detecting the presence, location or quantity of targets using novel dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-20100041020-A1 | Methods for detecting the presence, location or quantity of targets using novel dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-7569695-B2 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569695-B2 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-7569695-B2 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-20080153816-A1 | Indole Compounds, Method of Preparing Them and Uses Thereof | LABORATOIRES FOURNIER S.A. (FR) | 2008-06-26 | — | — | US | disclosed |
| US-20060269926-A1 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170313659-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SERPINB1, ELANE | POLB 1161/4885SMN1; SMN2 3019/4885ALDH1A1 514/4885 |
| US-20060269926-A1 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | OXA1L, ORMDL3, INMT | POLB 635/4885SMN1; SMN2 3898/4885ALDH1A1 2523/4885 |
| US-12391680-B2 | Compounds and compositions for the treatment of cystic fibrosis | CFTR, ABCB11, ABCC5 | POLB 1883/4885SMN1; SMN2 4551/4885ALDH1A1 2567/4885 |
| US-20080153816-A1 | Indole Compounds, Method of Preparing Them and Uses Thereof | LIPG, GPR119, IAPP | POLB 4410/4885SMN1; SMN2 2892/4885ALDH1A1 1607/4885 |
| US-20140371238-A1 | COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, SERPINB1, ELANE | POLB 1161/4885SMN1; SMN2 3019/4885ALDH1A1 514/4885 |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ANXA5, POLRMT, DCLRE1B | POLB 28/4885SMN1; SMN2 4048/4885ALDH1A1 4004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.