Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 12/20 | 1.00 |
| ▸ | ALOX12 | P18054 | 12/20 | 1.00 |
| ▸ | MEN1 | O00255 | 11/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 11/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 10/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 9/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | HTT | P42858 | 9/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 1.00 |
| ▸ | LMNA | P02545 | 8/20 | 1.00 |
| ▸ | PSMD14 | O00487 | 2/20 | 1.00 |
| ▸ | MMP2 | P08253 | 2/20 | 1.00 |
| ▸ | TP53 | P04637 | 1/20 | 1.00 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.88 |
| ▸ | GAA | P10253 | 1/20 | 0.80 |
| ▸ | BLM | P54132 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.75 |
| ▸ | NPC1 | O15118 | 6/20 | 0.74 |
| ▸ | RAB9A | P51151 | 6/20 | 0.74 |
| ▸ | HSP90AA1 | P07900 | 4/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26241605 | 0.96 | ALOX12 (0.92) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL610895 | 0.94 | ALOX12 (1.00) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL608048 | 0.89 | KDM4E (1.00) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL1541934 | 0.88 | ALOX12 (1.00) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL609917 | 0.85 | KDM4E (1.00) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL609671 | 0.85 | KDM4E (1.00) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL2153921 | 0.85 | KDM4E (0.77) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL30876651 | 0.84 | KDM4E (0.74) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL2153870 | 0.84 | KDM4E (0.74) | KDM4EALOX12MEN1KMT2AL3MBTL1 | |
| SCHEMBL27196457 | 0.84 | KDM4E (0.74) | KDM4EALOX12MEN1KMT2AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2021-07-01 | — | — | US | claimed |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-11-23 | — | — | US | claimed |
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-07-30 | — | — | US | claimed |
| US-9000009-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-04-07 | — | — | US | claimed |
| WO-2010068767-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-17 | — | — | WO | claimed |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | SIERRA SCIENCES, INC. (US) | 2023-07-18 | — | — | US | disclosed |
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2021-07-01 | — | — | US | disclosed |
| US-10745390-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2020-08-18 | — | — | US | disclosed |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-11-23 | — | — | US | disclosed |
| US-9695157-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2017-07-04 | — | — | US | disclosed |
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-07-30 | — | — | US | disclosed |
| US-9000009-B2 | Small molecule activators of mitochondrial function | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2015-04-07 | — | — | US | disclosed |
| US-20120041023-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2012-02-16 | — | — | US | disclosed |
| WO-2010068767-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2010-06-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150210674-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | KDM4E 4095/4885ALOX12 678/4885MEN1 4113/4885 |
| US-11701374-B1 | 8-hydroxy quinoline derivatives for enhancing telomerase reverse transcriptase (TERT) expression | TERT, TERF2, RNGTT | KDM4E 1300/4885ALOX12 3130/4885MEN1 3550/4885 |
| US-20170334890-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | KDM4E 4095/4885ALOX12 678/4885MEN1 4113/4885 |
| US-20120041023-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | KDM4E 4129/4885ALOX12 768/4885MEN1 4050/4885 |
| US-10745390-B2 | Small molecule activators of mitochondrial function | TFAM, TFB2M, GFM1 | KDM4E 4095/4885ALOX12 678/4885MEN1 4113/4885 |
| US-20210198244-A1 | SMALL MOLECULE ACTIVATORS OF MITOCHONDRIAL FUNCTION | TFAM, TFB2M, GFM1 | KDM4E 4095/4885ALOX12 678/4885MEN1 4113/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.