Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 3/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.40 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | P4HB | P07237 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105640 | 0.93 | VCAM1 (0.46) | CNR2MCHR1VCAM1SERPINE1MAPT | |
| SCHEMBL611706 | 0.81 | MAPT (0.40) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL316391 | 0.79 | MAPT (0.41) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL7611913 | 0.74 | CNR2 (0.67) | CNR2MCHR1VCAM1SERPINE1MAPT | |
| SCHEMBL9307801 | 0.74 | CNR2 (0.67) | CNR2MCHR1VCAM1SERPINE1MAPT | |
| SCHEMBL8101278 | 0.73 | CNR2 (0.64) | CNR2MCHR1VCAM1SERPINE1ALDH1A1 | |
| SCHEMBL9199430 | 0.72 | MAPT (0.53) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL1105775 | 0.72 | KDM4E (0.42) | VCAM1ALDH1A1MAPTSMN1; SMN2POLB | |
| SCHEMBL316151 | 0.72 | ALDH1A1 (0.57) | ALDH1A1MAPTSMN1; SMN2POLBLMNA | |
| SCHEMBL1105772 | 0.72 | INSR (0.52) | CNR2P4HB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846952-B2 | Detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes | ENZO LIFE SCIENCES, INC. (US) | 2014-09-30 | — | — | US | disclosed |
| US-8759526-B2 | Dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes—useful or detection or quantification of desirable target molecules | ENZO LIFE SCIENCES, INC. (US) | 2014-06-24 | — | — | US | disclosed |
| US-8574881-B2 | Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes | ENZO LIFE SCIENCES, INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20130109847-A1 | Detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2013-05-02 | — | — | US | disclosed |
| US-8389729-B2 | Methods for detecting the presence, location or quantity of targets using novel dyes | ENZO LIFE SCIENCES, INC. (US) | 2013-03-05 | — | — | US | disclosed |
| US-20130045480-A1 | Novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes - useful or detection or quantification of desirable target molecules | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2013-02-21 | — | — | US | disclosed |
| US-8153802-B2 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ENZO LIFE SCIENCES, INC. (US) | 2012-04-10 | — | — | US | disclosed |
| US-20120040430-A1 | Compositions useful for detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2012-02-16 | — | — | US | disclosed |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100041020-A1 | Methods for detecting the presence, location or quantity of targets using novel dyes | ENZO LIFE SCIENCES, INC. C/O ENZO BIOCHEM, INC. (US) | 2010-02-18 | — | — | US | disclosed |
| US-7569695-B2 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. (US) | 2009-08-04 | — | — | US | disclosed |
| US-20060269926-A1 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | ENZO LIFE SCIENCES, INC. | 2006-11-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060269926-A1 | Cyanine dyes substituted by electrophilic groups and/or nucleophilic groups including merocyanine, methine, oxazoline, oxonol, selenazole fluorescent, imidazoline, quinoline, indole, reactive and cationic dyes; labeling reagents for proteins and nucleic acids; genetic probes; amplification; hybridization | OXA1L, ORMDL3, INMT | CNR2 3117/4885MCHR1 1153/4885VCAM1 3144/4885 |
| US-20130045480-A1 | Novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes - useful or detection or quantification of desirable target molecules | ANXA5, DCLRE1B, ANXA4 | CNR2 4659/4885MCHR1 2403/4885VCAM1 525/4885 |
| US-20130109847-A1 | Detection or quantification of desirable target molecules, novel dyes, composite dyes, and oligonucleotides or polynucleotides comprising such dyes | ANXA5, DCLRE1B, POLRMT | CNR2 4566/4885MCHR1 2505/4885VCAM1 507/4885 |
| US-20100228008-A1 | Dyes linked to target molecules, oligonucleotides or polynucleotides comprising dye molecules, composite dyes and other compositions useful for detecting or quantifying desirable target molecules | ANXA5, POLRMT, DCLRE1B | CNR2 4513/4885MCHR1 2577/4885VCAM1 425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.