Acetic Acid

Acetic Acid

SCHEMBL612326

C=CCC1(CN)CCCCC1.CC(=O)O.Cl

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.55
CYP1A2 P05177 2/20 0.55
USP2 O75604 1/20 0.55
LMNA P02545 1/20 0.55
TSHR P16473 1/20 0.55
BLM P54132 1/20 0.55
CACNA2D1 P54289 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.55
KMT2A Q03164 3/20 0.41
MEN1 O00255 2/20 0.41
POLB P06746 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2351774 0.85 ALDH1A1 (0.48) ALDH1A1CYP1A2USP2LMNATSHR
SCHEMBL23458981 0.83 ALDH1A1 (0.45) ALDH1A1CYP1A2USP2LMNATSHR
SCHEMBL225199 0.78 ALDH1A1 (0.57) ALDH1A1CYP1A2USP2LMNATSHR
SCHEMBL14390606 0.76 ALDH1A1 (0.53) ALDH1A1CYP1A2USP2LMNATSHR
Acetic Acid SCHEMBL5891648 0.76 ALDH1A1 (0.59) ALDH1A1CYP1A2USP2LMNATSHR
SCHEMBL20189848 0.74
Gabapentin SCHEMBL26730 0.74 CYP1A2 (0.96) ALDH1A1CYP1A2USP2LMNATSHR
Hydrochloric Acid SCHEMBL7340062 0.74 CYP1A2 (0.96) ALDH1A1CYP1A2USP2LMNATSHR
Gabapentin SCHEMBL6689206 0.74 CYP1A2 (0.96) ALDH1A1CYP1A2USP2LMNATSHR
Bicarbonate SCHEMBL25218329 0.72 ALDH1A1 (0.71) ALDH1A1CYP1A2USP2LMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010075520-A1 PREPARATION OF GABAPENTIN ENACARBIL INTERMEDIATE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2010-07-01 WO claimed
US-20100160666-A1 PREPARATION OF GABAPENTIN ENACARBIL INTERMEDIATE TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) 2010-06-24 US claimed
US-20200283376-A1 Crystalline Form of y-Aminobutyric Acid Analog ARBOR PHARMACEUTICALS, LLC 2020-09-10 US disclosed
US-20190152900-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG ARBOR PHARMACEUTICALS LLC (US) 2019-05-23 US disclosed
US-20170183296-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG ARBOR PHARMACEUTICALS, LLC 2017-06-29 US disclosed
US-20150353483-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG XENOPORT, INC. (US) 2015-12-10 US disclosed
US-9150503-B2 Crystalline form of γ-aminobutyric acid analog XENOPORT, INC. (US) 2015-10-06 US disclosed
US-20140235710-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG XENOPORT, INC. (US) 2014-08-21 US disclosed
EP-2275401-B1 Crystalline 1-{[(alpha-isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid XENOPORT INC (US) 2013-04-03 EP disclosed
US-20120041061-A1 USE OF PRODRUGS OF GABA ANALOGS FOR TREATING DISEASES XENOPORT INC. 2012-02-16 US disclosed
US-20110313036-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG XENOPORT, INC. (US) 2011-12-22 US disclosed
US-20080058546-A1 Methods for Synthesis of Acyloxyalkyl Derivatives of GABA Analogs XENOPORT, INC 2008-03-06 US disclosed
US-7232924-B2 Methods for synthesis of acyloxyalkyl derivatives of GABA analogs XENOPORT, INC. (US) 2007-06-19 US disclosed
US-20070049627-A1 Treating vulvodynia using prodrugs of GABA analogs XENOPORT, INC. 2007-03-01 US disclosed
US-20060287250-A1 Methods for synthesis of acyloxyalkyl derivatives of GABA analogs XENOPORT, INC. 2006-12-21 US disclosed
EP-1554237-A4 METHODS FOR SYNTHESIS OF ACYLOXYALKYL DERIVATIVES OF GABA ANALOGS XENOPORT INC (US) 2006-11-02 EP disclosed
EP-1554237-A1 METHODS FOR SYNTHESIS OF ACYLOXYALKYL DERIVATIVES OF GABA ANALOGS Xenoport, Inc. (US) 2005-07-20 EP disclosed
US-20050154057-A1 Crystalline 1-{[( alpha -isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid; may be used as therapeutic agents in the treatment of neuropathic pain and post-herpetic neuralgia HPS INVESTMENT PARTNERS, LLC, AS ADMINISTRATIVE AGENT 2005-07-14 US disclosed
US-20040014940-A1 Methods for synthesis of acyloxyalkyl derivatives of GABA analogs XENOPORT, INC. 2004-01-22 US disclosed
WO-2003104184-A1 METHODS FOR SYNTHESIS OF ACYLOXYALKYL DERIVATIVES OF GABA ANALOGS XENOPORT, INC. (US) 2003-12-18 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (13 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190152900-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG GABRB2, GABRB1, GABRB3 ALDH1A1 1810/4885CYP1A2 1310/4885USP2 1318/4885
US-20040014940-A1 Methods for synthesis of acyloxyalkyl derivatives of GABA analogs GABRB1, GABRB3, GABBR1 ALDH1A1 495/4885CYP1A2 1323/4885USP2 1225/4885
US-20140235710-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG GABRB2, GABRB1, GABRB3 ALDH1A1 1810/4885CYP1A2 1310/4885USP2 1318/4885
US-20110313036-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG GABRB2, GABRB1, GABRB3 ALDH1A1 1810/4885CYP1A2 1310/4885USP2 1318/4885
US-20120041061-A1 USE OF PRODRUGS OF GABA ANALOGS FOR TREATING DISEASES GABRB1, GABBR1, GABRB3 ALDH1A1 2545/4885CYP1A2 819/4885USP2 2656/4885
US-20060287250-A1 Methods for synthesis of acyloxyalkyl derivatives of GABA analogs GABRB1, GABRB3, GABBR1 ALDH1A1 495/4885CYP1A2 1323/4885USP2 1225/4885
US-20150353483-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG GABRB2, GABRB1, GABRB3 ALDH1A1 1810/4885CYP1A2 1310/4885USP2 1318/4885
US-20080058546-A1 Methods for Synthesis of Acyloxyalkyl Derivatives of GABA Analogs GABRB1, GABRB3, GABBR1 ALDH1A1 495/4885CYP1A2 1323/4885USP2 1225/4885
US-20100160666-A1 PREPARATION OF GABAPENTIN ENACARBIL INTERMEDIATE GABRB1, GABRB3, GABRB2 ALDH1A1 1149/4885CYP1A2 3043/4885USP2 4388/4885
US-20050154057-A1 Crystalline 1-{[( alpha -isobutanoyloxyethoxy)carbonyl]aminomethyl}-1-cyclohexane acetic acid; may be used as therapeutic agents in the treatment of neuropathic pain and post-herpetic neuralgia GABRB1, GABRP, GABRA1 ALDH1A1 798/4885CYP1A2 4021/4885USP2 1525/4885
US-20200283376-A1 Crystalline Form of y-Aminobutyric Acid Analog GABRB2, GABRB1, GABRB3 ALDH1A1 1810/4885CYP1A2 1310/4885USP2 1318/4885
US-20070049627-A1 Treating vulvodynia using prodrugs of GABA analogs GABBR1, GABBR2, GABRB3 ALDH1A1 445/4885CYP1A2 335/4885USP2 1317/4885
US-20170183296-A1 CRYSTALLINE FORM OF y-AMINOBUTYRIC ACID ANALOG GABRB2, GABRB1, GABRB3 ALDH1A1 1810/4885CYP1A2 1310/4885USP2 1318/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.