Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | EIF4E | P06730 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | TOP1 | P11387 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.45 |
| ▸ | THPO | P40225 | 1/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 3/20 | 0.41 |
| ▸ | CTSK | P43235 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12892511 | 0.68 | LMNA (0.52) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL12879161 | 0.67 | LMNA (0.54) | LMNASMN1; SMN2ALDH1A1GLAEIF4E | |
| SCHEMBL25700089 | 0.67 | CTSL (0.58) | LMNACTSBCTSKCTSSCAPN1 | |
| SCHEMBL13973861 | 0.67 | ECE1 (0.64) | LMNACTSBCTSKCTSSCAPN1 | |
| SCHEMBL7331078 | 0.67 | ECE1 (0.64) | LMNACTSBCTSKCTSSCAPN1 | |
| SCHEMBL7305552 | 0.67 | ECE1 (0.64) | LMNACTSBCTSKCTSSCAPN1 | |
| SCHEMBL16869653 | 0.67 | CTSL (0.50) | CTSBCTSKCTSSCAPN1CASP1 | |
| SCHEMBL1908598 | 0.66 | CTSK (0.62) | LMNACTSBCTSKCTSSCASP1 | |
| SCHEMBL28892051 | 0.66 | TRPM8 (0.62) | ALDH1A1CTSBCTSKCTSSCASP1 | |
| SCHEMBL10535596 | 0.66 | TRPM8 (0.62) | ALDH1A1CTSBCTSKCTSSCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572710-A2 | ANTIVIRAL NUCLEOSIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004052905-A2 | ANTIVIRAL NUCLEOSIDE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2004-06-24 | — | — | WO | disclosed |
| US-20040121969-A1 | Antiviral nucleoside derivatives | ROCHE PALO ALTO LLC | 2004-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040121969-A1 | Antiviral nucleoside derivatives | IMPDH1, IFNAR1, RNASEH1 | LMNA 4294/4885SMN1; SMN2 1510/4885ALDH1A1 403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.