Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | HTR1A | P08908 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.53 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6131824 | 0.86 | ALDH1A1 (0.66) | SIGMAR1DRD2HTR1AKDM4EALDH1A1 | |
| SCHEMBL6131940 | 0.81 | ADRA1D (0.70) | DRD2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6131787 | 0.79 | ADRA1D (0.59) | DRD2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6131986 | 0.79 | LMNA (0.60) | DRD2HTR1AKDM4EALDH1A1ADRA1D | |
| SCHEMBL5182094 | 0.78 | SIGMAR1 (0.66) | SIGMAR1KCNH2DRD2HTR1AHRH3 | |
| SCHEMBL6131837 | 0.78 | ALDH1A1 (0.65) | DRD2HTR1AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2110364 | 0.78 | TSHR (0.69) | SIGMAR1KCNH2ADRA1DADRA1AADRA1B | |
| SCHEMBL6131854 | 0.77 | HTR1A (0.58) | SIGMAR1DRD2HTR1AKDM4EALDH1A1 | |
| SCHEMBL1299348 | 0.77 | SIGMAR1 (0.79) | SIGMAR1 | |
| SCHEMBL15743241 | 0.77 | KCNH2 (0.76) | KCNH2DRD2HTR1AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032559-A4 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMA INC (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-1032559-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999016746-A1 | AMINOALKYLPHENOL DERIVATIVES AND RELATED COMPOUNDS | AVENTIS PHARMACEUTICALS INC. (US) | 1999-04-08 | — | — | WO | disclosed |