Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | XIAP | P98170 | 1/20 | 0.35 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CASP7 | P55210 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133425 | 0.87 | RET (0.41) | TP53POLBKMT2AXIAPP2RY6 | |
| SCHEMBL6134642 | 0.86 | TP53 (0.41) | TP53POLBXIAPP2RY6NPC1 | |
| SCHEMBL6133813 | 0.85 | ALOX15 (0.46) | TP53POLBKMT2AMEN1XIAP | |
| SCHEMBL6133894 | 0.84 | TP53 (0.36) | TP53POLBXIAPP2RY6KDM4E | |
| SCHEMBL6924703 | 0.83 | CAMK2D (0.42) | TP53POLBKMT2AHPGDKDM4E | |
| SCHEMBL6133811 | 0.83 | NPC1 (0.40) | TP53POLBXIAPSMN1; SMN2NPC1 | |
| SCHEMBL6133228 | 0.83 | XIAP (0.48) | TP53KMT2AMEN1XIAPALDH1A1 | |
| SCHEMBL6133914 | 0.82 | HPGD (0.42) | TP53POLBKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6133924 | 0.82 | PTGS2 (0.44) | KMT2AMEN1SMN1; SMN2NPC1HPGD | |
| SCHEMBL6134884 | 0.82 | ALDH1A1 (0.40) | TP53POLBKMT2AMEN1XIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | TP53 4124/4885POLB 3447/4885KMT2A 2724/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.