Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.33 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.32 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.32 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133040 | 0.88 | GABRA5 (0.40) | HDAC6HDAC1PTGS2ADORA2AADORA1 | |
| SCHEMBL6134790 | 0.87 | TGFBR1 (0.41) | HDAC6HDAC1HDAC3KCNH2HDAC2 | |
| SCHEMBL6923908 | 0.87 | HDAC6 (0.35) | HDAC6HDAC1HDAC3KCNH2HDAC2 | |
| SCHEMBL6133930 | 0.86 | RET (0.42) | HDAC6PTGS2ADORA2AADORA1RET | |
| SCHEMBL6133269 | 0.85 | HPGD (0.42) | HDAC6TGFBR1NPC1RAB9AGABRA5 | |
| SCHEMBL6133569 | 0.85 | HDAC6 (0.45) | HDAC6HDAC1HDAC3KCNH2HDAC2 | |
| SCHEMBL6133196 | 0.82 | L3MBTL1 (0.40) | HDAC6KCNH2HSD17B10ALDH1A1 | |
| SCHEMBL6133158 | 0.82 | PTGS2 (0.56) | PTGS2TGFBR1NPC1RAB9AHSD17B10 | |
| SCHEMBL6133345 | 0.80 | SMN1; SMN2 (0.49) | ADORA2AADORA1NPC1RAB9AHSD17B10 | |
| SCHEMBL6133441 | 0.80 | ALDH1A1 (0.47) | KCNH2ADORA2AADORA1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | HDAC6 222/4885HDAC1 601/4885HDAC3 388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.