Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | APAF1 | O14727 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5147931 | 0.81 | POLB (0.44) | HPGDRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5797395 | 0.74 | HTR2C (0.43) | RAB9AKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL1811078 | 0.74 | PKM (0.36) | PKMRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5149093 | 0.71 | L3MBTL1 (0.48) | PKMHPGDRAB9AKDM4EALDH1A1 | |
| SCHEMBL16618386 | 0.70 | HPGD (0.47) | HPGDRAB9AKDM4ESMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL16616453 | 0.69 | HPGD (0.46) | HPGDRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL11636011 | 0.69 | KDM4E (0.55) | HPGDRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL5798675 | 0.68 | CYP1A2 (0.43) | HPGDRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL10796459 | 0.67 | RAB9A (0.49) | HPGDRAB9AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL1449523 | 0.67 | HSD11B1 (0.49) | HPGDRAB9AKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | PKM 1156/4885HPGD 521/4885RAB9A 1824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.