Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | OGA | O60502 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6139376 | 0.83 | LMNA (0.55) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7921619 | 0.82 | LMNA (0.49) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7915514 | 0.80 | ALDH1A1 (0.55) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7921621 | 0.79 | ALDH1A1 (0.76) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7921747 | 0.77 | LMNA (0.62) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7921771 | 0.76 | LMNA (0.61) | LMNAALDH1A1TSHRTP53MAPT | |
| SCHEMBL7594639 | 0.76 | LMNA (0.61) | LMNAALDH1A1TSHRTP53MAPT | |
| SCHEMBL7915455 | 0.76 | LMNA (0.58) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7924002 | 0.75 | LMNA (0.59) | LMNAALDH1A1TSHRTP53HTT | |
| SCHEMBL7921975 | 0.75 | ALDH1A1 (0.60) | LMNAALDH1A1TSHRTP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-06-16 | — | — | US | claimed |
| EP-1504759-A1 | ORAL THERAPEUTIC OR PREVENTIVE DRUGS FOR POLLAKIURIA AND URINARY INCONTINENCE OR ORAL SLEEP INDUCERS, CONTAINING TROPOLONE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2005-02-09 | — | — | EP | claimed |
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1504759-A1 | ORAL THERAPEUTIC OR PREVENTIVE DRUGS FOR POLLAKIURIA AND URINARY INCONTINENCE OR ORAL SLEEP INDUCERS, CONTAINING TROPOLONE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2005-02-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | MTNR1A, SULT2A1, MTNR1B | LMNA 2399/4885ALDH1A1 309/4885TSHR 2978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.