Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7924072 | 0.94 | LMNA (0.50) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7915276 | 0.93 | LMNA (0.53) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7921093 | 0.92 | LMNA (0.48) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7923524 | 0.92 | LMNA (0.48) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7921974 | 0.92 | CA12 (0.56) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7927261 | 0.92 | LMNA (0.48) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7927130 | 0.91 | MEN1 (0.54) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7923530 | 0.90 | CA12 (0.48) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7921573 | 0.89 | LMNA (0.58) | LMNAALDH1A1TSHRTP53MEN1 | |
| SCHEMBL7921648 | 0.88 | DRD4 (0.54) | LMNATSHRMAPTALOX15DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2005-06-16 | — | — | US | disclosed |
| EP-1504759-A1 | ORAL THERAPEUTIC OR PREVENTIVE DRUGS FOR POLLAKIURIA AND URINARY INCONTINENCE OR ORAL SLEEP INDUCERS, CONTAINING TROPOLONE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2005-02-09 | — | — | EP | disclosed |
| US-6221868-B1 | Remedies/preventives for frequent urination/urinary incontinence and tropone derivatives | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2001-04-24 | — | — | US | disclosed |
| EP-0995741-A1 | REMEDIES/PREVENTIVES FOR FREQUENT URINATION/URINARY INCONTINENCE AND TROPONE DERIVATIVES | Nippon Kayaku Kabushiki Kaisha (JP) | 2000-04-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050130982-A1 | Oral therapeutic or preventative drugs for pollakiuria and urinary incontinence and oral sleep inducers, containing tropolone derivatives | MTNR1A, SULT2A1, MTNR1B | LMNA 2399/4885ALDH1A1 309/4885TSHR 2978/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.