Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Methyprylon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyprylon SCHEMBL155839 | 1.00 | LMNA (0.40) | LMNACYP19A1TSHRNPSR1ALDH1A1 | |
| Methyprylon SCHEMBL155838 | 1.00 | LMNA (0.40) | LMNACYP19A1TSHRNPSR1ALDH1A1 | |
| Methyprylon SCHEMBL10792726 | 0.96 | LMNA (0.38) | LMNACYP19A1 | |
| Methyprylon SCHEMBL6695974 | 0.91 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL7683591 | 0.91 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL9014931 | 0.91 | LMNA (0.34) | LMNACYP19A1 | |
| Methyprylon SCHEMBL8663851 | 0.90 | LMNA (0.33) | LMNACYP19A1 | |
| Methyprylon SCHEMBL1326559 | 0.87 | LMNA (0.32) | LMNACYP19A1 | |
| Methyprylon SCHEMBL623597 | 0.87 | LMNA (0.32) | LMNACYP19A1 | |
| Methyprylon SCHEMBL4561157 | 0.86 | TP53 (0.32) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 385336 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6436477-B1 | — | — | None | — | — | US | claimed |
| CN-119183458-A | Heterophasic polypropylene composition with low hexane extract | SABIC环球技术有限责任公司 | 2024-12-24 | — | — | CN | claimed |
| CN-118745317-B | Double-component transparent polyurea coating and preparation method thereof | 北京宇阳泽丽防水材料有限责任公司 | 2024-12-13 | — | — | CN | claimed |
| WO-2024251238-A1 | NOVEL DECAPEPTIDE AND USE THEREOF IN ANTIBACTERIAL | 南京迈西可生物科技有限公司 | 2024-12-12 | — | — | WO | claimed |
| CN-119095833-A | Gamma-hydroxybutyrate delivery compounds and methods of making and using the same | 泽夫拉治疗公司 | 2024-12-06 | — | — | CN | claimed |
| CN-118994107-A | Solid forms of a compound | 成都苑东生物制药股份有限公司 | 2024-11-22 | — | — | CN | claimed |
| US-20240374523-A1 | STABILIZED APILIMOD COMPOSITIONS AND USES THEREOF | ACADIA WOODS PARTNERS, LLC | 2024-11-14 | — | — | US | claimed |
| WO-2024232884-A1 | ORAL DOSAGE FORMS OF METFORMIN AND PREPARATION METHOD THEREOF | Elite Pharmaceutical Solution Inc. (US) | 2024-11-14 | — | — | WO | claimed |
| CN-118931413-A | Organic silicon packaging adhesive film with high light transmittance and preparation method thereof | 浙江迪脉新材料有限公司 | 2024-11-12 | — | — | CN | claimed |
| WO-2024228768-A1 | HYDROFORMYLATION PROCESS | DOW TECHNOLOGY INVESTMENTS LLC (US) | 2024-11-07 | — | — | WO | claimed |
| US-3952061-A | Method of isomerizing humulone to isohumulone by catalytic acceleration with metal salts | ATLANTIC RESEARCH INSTITUTE LIMITED (BA) | 1976-04-20 | — | — | US | claimed |
| US-3950354-A | ANTIMYCOTIC AGENTS | BAYER AKTIENGESELLSCHAFT (DT) | 1976-04-13 | — | — | US | claimed |
| US-3941735-A | Aqueous emulsion adhesive of a copolymer of an alcohol ether of N-methylol derivative of an allyl carbamate which develops water resistance through cure | CHAS. S. TANNER CO. (US) | 1976-03-02 | — | — | US | claimed |
| US-3941718-A | Insoluble crosslinked homopolymers and copolymers, polymerized on an inert substrate | GAF CORPORATION (US) | 1976-03-02 | — | — | US | claimed |
| US-3940413-A | ANTIMYCOTIC | BAYER AKTIENGESELLSCHAFT (DT) | 1976-02-24 | — | — | US | claimed |
| US-3936575-A | PRINTED CIRCUITS | SUMITOMO BAKELITE COMPANY, LIMITED (JA) | 1976-02-03 | — | — | US | claimed |
| US-3935136-A | SUSPENSION POLYMERIZATION, CROSSLINKING | PHILLIPS PETROLEUM COMPANY (US) | 1976-01-27 | — | — | US | claimed |
| US-3934015-A | NITROGEN HETEROCYCLIC SUBSTITUTED PHENOLS | HOFFMANN-LA ROCHE INC. (US) | 1976-01-20 | — | — | US | claimed |
| US-3932333-A | POLYELECTROLYTES | MONSANTO COMPANY (US) | 1976-01-13 | — | — | US | claimed |
| US-3931400-A | CULTIVATION OF MICROMONOSPORA, ANTIBIOTIC | ABBOTT LABORATORIES (US) | 1976-01-06 | — | — | US | claimed |