Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MET | P08581 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CTSB | P07858 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.33 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27523568 | 0.86 | ALDH1A1 (0.37) | ALDH1A1LMNAMAPTMETTDP1 | |
| SCHEMBL15208581 | 0.84 | ALDH1A1 (0.36) | ALDH1A1LMNAMAPTMETKDM4E | |
| SCHEMBL2860553 | 0.84 | MET (0.40) | ALDH1A1LMNAMAPTMETTDP1 | |
| SCHEMBL20916666 | 0.82 | FBP1 (0.36) | ALDH1A1LMNAMAPTMETTDP1 | |
| SCHEMBL6581323 | 0.81 | HTT (0.39) | ALDH1A1LMNAMAPTMETTDP1 | |
| SCHEMBL6142331 | 0.79 | HSP90AA1 (0.37) | MAPTTSHRSMN1; SMN2GPR119MEN1 | |
| SCHEMBL6954330 | 0.79 | MAPT (0.36) | ALDH1A1LMNAMAPTMETTDP1 | |
| SCHEMBL7345451 | 0.78 | STS (0.38) | ALDH1A1TSHRGPR119MEN1KMT2A | |
| SCHEMBL15208411 | 0.75 | ALDH1A1 (0.48) | ALDH1A1LMNAMAPTSMN1; SMN2KDM4E | |
| SCHEMBL25339042 | 0.74 | ALDH1A1 (0.39) | ALDH1A1LMNAMAPTMETTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944604-B1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2005-01-12 | — | — | EP | disclosed |
| EP-0944601-B1 | GUANIDINYLAMINO HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2003-02-12 | — | — | EP | disclosed |
| US-20020128481-A1 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists | CUPPS THOMAS LEE (US) | 2002-09-12 | — | — | US | disclosed |
| US-6436978-B1 | FOR PREVENTING OR TREATING DISORDERS MODULATED BY ALPHA-2 ADRENOCEPTORS | THE PROCTER & GAMBLE CO. | 2002-08-20 | — | — | US | disclosed |
| US-20020095039-A1 | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists | CUPPS THOMAS LEE (US) | 2002-07-18 | — | — | US | disclosed |
| US-6391878-B2 | COMPOUNDS SUCH AS (4,7-DIMETHYLBENZIMIDAZOL-5-YL)GUANIDINE; TREATING NASAL CONGESTION, OTITIS MEDIA, ASTHMA, PAIN, MIGRAINE, GASTROINTESTINAL DISORDER, ULCER | THE PROCTER & GAMBLE COMPANY | 2002-05-21 | — | — | US | disclosed |
| US-20020028950-A1 | Guanidinylamino heterocycle compunds useful as alpha-2 adrenoceptor agonists | CUPPS THOMAS LEE (US) | 2002-03-07 | — | — | US | disclosed |
| US-6306877-B1 | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists | THE PROCTER & GAMBLE CO. | 2001-10-23 | — | — | US | disclosed |
| US-6225331-B1 | FOR THERAPY AND PROPHYLAXIS NASAL CONGESTION, OTITIS MEDIA, AND SINUSITIS, TREATING COUGH, CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND/OR ASTHMA, BENIGN PROSTATIC HYPERTROPHY, CARDIOVASCULAR DISORDERS, GLAUCOMA, HYPEREMIA, CONJUNCTIVITIS | THE PROCTER & GAMBLE COMPANY | 2001-05-01 | — | — | US | disclosed |
| US-20010000345-A1 | Compounds such as (4,7-dimethylbenzimidazol-5-yl)guanidine; treating nasal congestion, otitis media, asthma, pain, migraine, gastrointestinal disorder, ulcer | THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA | 2001-04-19 | — | — | US | disclosed |
| US-6172095-B1 | DECONGESTANTS, ANALGESICS, HYPOTENSIVE AGENTS; TREATING HEADACHES, OTITIS MEDIA, SINUSITUS, GASTROINTESTINAL AND RESPIRATORY SYSTEM DISORDERS; SIDE EFFECT REDUCTION | THE PROCTER & GAMBLE COMPANY | 2001-01-09 | — | — | US | disclosed |
| EP-0944604-A1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023596-A1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |
| US-5691370-A | 5-(2-imidazolinylamino)benzimidazole compounds useful as alpha-2-adrenoceptor agonists | THE PROCTER & GAMBLE COMPANY (US) | 1997-11-25 | — | — | US | disclosed |
| US-5541210-A | ANALGESICS, ANTIINFLAMMATORY AGENTS, ANTIHISTAMINES OR COUGH MEDICINE | THE PROCTER & GAMBLE COMPANY (US) | 1996-07-30 | — | — | US | disclosed |
| US-5478858-A | Respiratory system disorders, gastrointestinal disorders | THE PROCTER & GAMBLE COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020095039-A1 | Guanidinylamino heterocycle compounds useful as alpha-2 adrenoceptor agonists | ADRB2, ADRA2C, ADRA2A | ALDH1A1 652/4885LMNA 772/4885MAPT 318/4885 |
| US-20020028950-A1 | Guanidinylamino heterocycle compunds useful as alpha-2 adrenoceptor agonists | ADRB2, ADRA2C, ADRA2A | ALDH1A1 655/4885LMNA 1351/4885MAPT 652/4885 |
| US-20010000345-A1 | Compounds such as (4,7-dimethylbenzimidazol-5-yl)guanidine; treating nasal congestion, otitis media, asthma, pain, migraine, gastrointestinal disorder, ulcer | ADRB2, ADRA2C, ADRA2B | ALDH1A1 1083/4885LMNA 954/4885MAPT 938/4885 |
| US-20020128481-A1 | Guanidinyl heterocycle compounds useful as alpha-2 adrenoceptor agonists | ADRB2, ADRA2C, ADRA2A | ALDH1A1 722/4885LMNA 849/4885MAPT 312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.