Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PNLIP | P16233 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1028223 | 0.85 | POLB (0.48) | ALDH1A1LMNAL3MBTL1TRPA1ATM | |
| SCHEMBL9837352 | 0.80 | ALDH1A1 (0.53) | ALDH1A1LMNAL3MBTL1PNLIPHTT | |
| SCHEMBL6293301 | 0.80 | HSPB1 (0.43) | ALDH1A1LMNAL3MBTL1HTTMAPK1 | |
| SCHEMBL6293895 | 0.76 | ALDH1A1 (0.45) | ALDH1A1LMNAL3MBTL1HTTMAPK1 | |
| SCHEMBL28737745 | 0.75 | L3MBTL1 (0.47) | ALDH1A1L3MBTL1ATMRAB9AKDM4E | |
| SCHEMBL9749287 | 0.74 | PDGFRA (0.41) | ALDH1A1LMNAL3MBTL1TRPA1MEN1 | |
| SCHEMBL24445839 | 0.73 | TRPA1 (0.50) | ALDH1A1LMNAL3MBTL1TRPA1ATM | |
| SCHEMBL9742890 | 0.73 | LMNA (0.52) | ALDH1A1LMNAL3MBTL1TRPA1PNLIP | |
| SCHEMBL6290676 | 0.73 | ALDH1A1 (0.61) | ALDH1A1LMNAL3MBTL1HTTMEN1 | |
| SCHEMBL3755350 | 0.72 | ALDH1A1 (0.53) | ALDH1A1LMNAL3MBTL1HTTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517882-A1 | AMIDE LINKER PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000789-A1 | AMIDE LINKER PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-12-31 | — | — | WO | disclosed |