Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
| ▸ | PRKDC | P78527 | 2/20 | 0.34 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6156220 | 0.90 | PDE3B (0.46) | PDE3BPDE3APRKDC | |
| SCHEMBL6156255 | 0.87 | MEN1 (0.38) | PDE3BPDE3APRKDCALDH1A1 | |
| SCHEMBL6158814 | 0.85 | PRKDC (0.37) | PDE3BPDE3APRKDCALDH1A1 | |
| SCHEMBL6156871 | 0.84 | KDM4E (0.42) | PDE3BPDE3APRKDCALDH1A1 | |
| SCHEMBL8371288 | 0.83 | PDE3B (0.39) | PDE3BPDE3APRKDCALDH1A1 | |
| SCHEMBL6165736 | 0.81 | PTPN1 (0.38) | PDE3BPDE3APRKDCALDH1A1 | |
| SCHEMBL6155515 | 0.80 | RAB9A (0.33) | PDE3BPDE3APRKDCALDH1A1 | |
| SCHEMBL6155845 | 0.78 | KMT2A (0.34) | ALDH1A1LMNA | |
| SCHEMBL6156254 | 0.78 | KDM4E (0.35) | ALDH1A1 | |
| SCHEMBL7784158 | 0.77 | ALDH1A1 (0.45) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0894805-B1 | Ribose substituted aromatic derivatives, their preparation and use as medicaments | AVENTIS PHARMA SA (FR) | 2005-02-09 | — | — | EP | disclosed |
| EP-0894805-A1 | Ribose substituted aromatic derivatives, their preparation and use as medicaments | HOECHST MARION ROUSSEL (FR) | 1999-02-03 | — | — | EP | disclosed |