Agathisflavone

Agathisflavone

SCHEMBL616142

O=c1cc(-c2ccc(O)cc2)oc2cc(O)c(-c3c(O)cc(O)c4c(=O)cc(-c5ccc(O)cc5)oc34)c(O)c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CBS P35520 2/20 1.00
PTPN1 P18031 2/20 0.80
CDK5 Q00535 2/20 0.80
CDK5R1 Q15078 2/20 0.80
APP P05067 6/20 0.78
KMT2A Q03164 5/20 0.67
PKM P14618 4/20 0.67
GABRP O00591 3/20 0.67
GABRD O14764 3/20 0.67
GABRA1 P14867 3/20 0.67
GABRB1 P18505 3/20 0.67
GABRG2 P18507 3/20 0.67
GABRB3 P28472 3/20 0.67
GABRA5 P31644 3/20 0.67
GABRA3 P34903 3/20 0.67
GABRA2 P47869 3/20 0.67
GABRB2 P47870 3/20 0.67
GABRA4 P48169 3/20 0.67
GABRE P78334 3/20 0.67
GABRA6 Q16445 3/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Agathisflavone SCHEMBL30637380 1.00 CBS (1.00) CBSPTPN1CDK5CDK5R1APP
SCHEMBL30442786 0.91 CBS (0.82) CBSPTPN1CDK5CDK5R1APP
SCHEMBL24088771 0.91 CBS (0.82) CBSPTPN1CDK5CDK5R1APP
Cupressuflavone SCHEMBL31670258 0.89 CBS (1.00) CBSPTPN1CDK5CDK5R1APP
Cupressuflavone SCHEMBL505213 0.89 CBS (1.00) CBSPTPN1CDK5CDK5R1APP
Cupressuflavone SCHEMBL4650575 0.88 CBS (0.97) CBSPTPN1CDK5CDK5R1APP
SCHEMBL15899618 0.85 APP (0.77) CBSPTPN1CDK5CDK5R1APP
SCHEMBL25858984 0.85 CBS (0.73) CBSPTPN1CDK5CDK5R1APP
SCHEMBL30646164 0.84 APP (1.00) CBSPTPN1CDK5CDK5R1APP
SCHEMBL27350769 0.84 APP (1.00) CBSPTPN1CDK5CDK5R1APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023219526-A1 MULTITARGET ANTIVIRAL DIETARY SUPPLEMENT PROKIN MILAN (RS) 2023-11-16 WO claimed
CN-103221056-A Electronically Modified Reaction Intermediates MARKOU DEMETRIOS 2013-07-24 CN claimed
EP-2603225-A2 ELECTRONICALLY MODIFIED REACTION INTERMIDEATES Markou, Demetrios (US) 2013-06-19 EP claimed
WO-2012024196-A2 A NOVEL METHOD FOR CREATING, SUSPENDING AND STABILIZING ELECTRONICALLY MODIFIED REACTION INTERMIDEATES MARKOU DEMETRIOS (US) 2012-02-23 WO claimed
US-20120039796-A1 Novel method for creating, suspending and stabilizing electronically modified oxygen derivatives, along with creating, suspending and stabilizing electronically modified reaction intermediates, in a bio compatible fluorocarbon suspension, for the purpose of inducing a cascading immune response in mammalian patients MARKOU DEMETRIOS (US) 2012-02-16 US claimed
WO-2009023803-A2 MODULATED RELEASE FORMULATION FOR THE DELIVERY OF ONE OR MORE MEDICAMENTS ABBOTT RESPIRATORY LLC (US) 2009-02-19 WO claimed
CN-101049301-A Pharmaceutical preparation of biflavone compound for anti gout HUIBEI COLLEGE OF CHINESE MEDI (CN) 2007-10-10 CN claimed
US-20020068757-A1 Biflavanoids and derivatives thereof as antiviral agents ADVANCED LIFE SCIENCES, INC. 2002-06-06 US claimed
US-6399654-B1 ADMINISTERING MIXTURE OF VIRICIDE AND BIOFLAVANOID ADVANCED LIFE SCIENCES, INC. 2002-06-04 US claimed
WO-1998046238-A1 BIFLAVINOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS, ALONE OR IN COMBINATION WITH AT LEAST ONE KNOWN ANTIVIRAL AGENT MEDICHEM RESEARCH, INC. (US) 1998-10-22 WO claimed
EP-0833631-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1998-04-08 EP claimed
WO-1997000679-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1997-01-09 WO claimed
US-20250228814-A1 COMBINATION THERAPIES FOR THE TREATMENT OF VIRAL INFECTIONS FLAGSHIP PIONEERING INNOVATIONS VI, LLC 2025-07-17 US disclosed
US-20250213601-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES Didenko, Kirill (US) 2025-07-03 US disclosed
US-20240390393-A1 BOTANICAL EXTRACTS AND COMPOUNDS FROM SCHINUS PLANTS AND METHODS OF USE EMORY UNIVERSITY (US) 2024-11-28 US disclosed
US-20240307413-A1 BOTANICAL EXTRACTS AND COMPOUNDS FROM SCHINUS PLANTS AND METHODS OF USE EMORY UNIVERSITY (US) 2024-09-19 US disclosed
EP-0833631-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1998-04-08 EP disclosed
EP-0833631-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1998-04-08 EP disclosed
WO-1997000679-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1997-01-09 WO disclosed
WO-1997000679-A1 BIFLAVANOIDS AND DERIVATIVES THEREOF AS ANTIVIRAL AGENTS MEDICHEM RESEARCH, INC. (US) 1997-01-09 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250228814-A1 COMBINATION THERAPIES FOR THE TREATMENT OF VIRAL INFECTIONS HAVCR2, EIF2AK2, MAVS CBS 3379/4885PTPN1 1321/4885CDK5 1699/4885
US-20240390393-A1 BOTANICAL EXTRACTS AND COMPOUNDS FROM SCHINUS PLANTS AND METHODS OF USE BROX, C5, SYMPK CBS 237/4885PTPN1 2016/4885CDK5 2934/4885
US-20020068757-A1 Biflavanoids and derivatives thereof as antiviral agents HK2, GYS2, HK1 CBS 3171/4885PTPN1 1427/4885CDK5 2719/4885
US-20250213601-A1 METHODS AND BIOAVAILABLE HIGHLY PERMEABLE COMPOUNDS FOR THE TREATMENT OF VIRAL DISEASES ACE2, FURIN, SARS1 CBS 1776/4885PTPN1 4387/4885CDK5 4599/4885
US-20240307413-A1 BOTANICAL EXTRACTS AND COMPOUNDS FROM SCHINUS PLANTS AND METHODS OF USE BROX, C5, SYMPK CBS 237/4885PTPN1 2016/4885CDK5 2934/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.