Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.57 |
| ▸ | HTR7 | P34969 | 7/20 | 0.57 |
| ▸ | HTR3A | P46098 | 7/20 | 0.55 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.55 |
| ▸ | HTR3B | O95264 | 1/20 | 0.55 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.55 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.55 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.51 |
| ▸ | HTR2B | P41595 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30609639 | 0.87 | HTR3A (0.61) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| SCHEMBL706971 | 0.87 | HTR3A (0.61) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| SCHEMBL6560075 | 0.86 | ADRB1 (0.62) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL709707 | 0.85 | HTR3A (0.59) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| SCHEMBL6162708 | 0.83 | L3MBTL1 (0.55) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL27477678 | 0.78 | HTR1A (0.54) | HTR1AHTR7HTR3AHTR2BHTR6 | |
| SCHEMBL4238177 | 0.77 | ADRB1 (0.58) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| SCHEMBL255197 | 0.76 | HTR3A (0.67) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| SCHEMBL6160209 | 0.76 | HTR7 (0.60) | HTR1AHTR7HTR3AHTR3EHTR3B | |
| Hydrochloric Acid SCHEMBL2534803 | 0.75 | HTR3A (0.68) | HTR1AHTR7HTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |