Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.43 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161142 | 0.82 | SIGMAR1 (0.58) | HRH3MMP3PARP14PARP10SIGMAR1 | |
| SCHEMBL6161283 | 0.76 | DRD2 (0.55) | HRH3MMP3SLC18A3DRD2 | |
| SCHEMBL6159046 | 0.75 | DRD2 (0.60) | MMP3PARP14PARP10SIGMAR1SLC18A3 | |
| SCHEMBL7474955 | 0.74 | ALDH1A1 (0.66) | MMP3DRD2 | |
| SCHEMBL7478048 | 0.74 | MMP3 (0.45) | HRH3MMP3PARP14PARP10SIGMAR1 | |
| Benzene SCHEMBL6163077 | 0.74 | PARP10 (0.47) | HRH3MMP3PARP14PARP10 | |
| SCHEMBL7469402 | 0.73 | HRH3 (0.60) | HRH3MMP3SIGMAR1SLC18A3DRD2 | |
| SCHEMBL27477245 | 0.73 | SLC18A3 (0.57) | HRH3MMP3SLC18A3DRD2 | |
| SCHEMBL12041706 | 0.73 | S1PR1 (0.69) | HRH3MMP3SIGMAR1SLC18A3DRD2 | |
| SCHEMBL7477521 | 0.72 | CHRM4 (0.59) | HRH3MMP3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755923-B1 | Ameliorant or remedy for symptoms caused by Ischemic diseases and Phenylpiperidine compounds useful therefor | DAIICHI SUNTORY PHARMA CO LTD (JP) | 2005-05-04 | — | — | EP | disclosed |
| US-6469010-B1 | COMPOSITION ALSO FOR ALLEVIATION OR TREATMENT OF SYMPTOMS DERIVED FROM SEIZURES, EPILEPSY AND MIGRAINE HEADACHES, AND SUPPRESSION OF CALCIUM ION OVERLOAD | SUNTORY LIMITED (JP) | 2002-10-22 | — | — | US | disclosed |
| US-6048876-A | ANTICONVULSANTS; ANTIEPILEPIC AGENT | SUNTORY LIMITED (JP) | 2000-04-11 | — | — | US | disclosed |
| EP-0755923-A1 | AMELIORANT OR REMEDY FOR SYMPTOMS CAUSED BY ISCHEMIC DISEASES AND COMPOUNDS USEFUL THEREFOR | SUNTORY LIMITED (JP) | 1997-01-29 | — | — | EP | disclosed |