Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP3 | P08254 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 2/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | LTA4H | P09960 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6161142 | 0.81 | SIGMAR1 (0.58) | MMP3PARP14PARP10SIGMAR1HRH3 | |
| SCHEMBL6163074 | 0.74 | HRH3 (0.47) | MMP3PARP14PARP10SIGMAR1DRD2 | |
| SCHEMBL6159046 | 0.73 | DRD2 (0.60) | MMP3PARP14PARP10SIGMAR1DRD2 | |
| SCHEMBL7474955 | 0.73 | ALDH1A1 (0.66) | MMP3LTA4HDRD2ALDH1A1LMNA | |
| SCHEMBL6161283 | 0.72 | DRD2 (0.55) | MMP3DRD2HRH3ALDH1A1SLC18A3 | |
| SCHEMBL12041706 | 0.72 | S1PR1 (0.69) | MMP3SIGMAR1DRD2HRH3ALDH1A1 | |
| SCHEMBL7477521 | 0.71 | CHRM4 (0.59) | MMP3SIGMAR1OPRM1HRH3 | |
| SCHEMBL381548 | 0.71 | S1PR1 (0.67) | MMP3SIGMAR1DRD2HRH3ALDH1A1 | |
| SCHEMBL7477194 | 0.71 | DRD4 (0.59) | MMP3DRD2ALDH1A1LMNAGAA | |
| SCHEMBL12041705 | 0.71 | HRH3 (0.55) | MMP3SIGMAR1OPRM1DRD2HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0757986-B1 | Arylpiperidine and arylpiperazine derivatives and drugs containing the same | SUNTORY LTD (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-5723475-A | Arylpiperidine and arylpiperazine derivatives and medicament containing the same | SUNTORY LIMITED (JP) | 1998-03-03 | — | — | US | disclosed |
| EP-0757986-A1 | ARYLPIPERIDINE AND ARYLPIPERAZINE DERIVATIVES AND DRUGS CONTAINING THE SAME | SUNTORY LIMITED (JP) | 1997-02-12 | — | — | EP | disclosed |