Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 3/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.31 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.31 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.30 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | ALPL | P05186 | 1/20 | 0.30 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.30 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886026 | 0.81 | PNP (0.35) | PNPPARP1ABL1RIN1ATAD2 | |
| SCHEMBL20576 | 0.79 | PNP (0.34) | PNPPARP1ABL1RIN1ATAD2 | |
| SCHEMBL2051359 | 0.79 | PNP (0.34) | PNPPARP1ABL1RIN1ATAD2 | |
| SCHEMBL1828928 | 0.79 | PNP (0.34) | PNPPARP1ABL1RIN1ATAD2 | |
| SCHEMBL20866 | 0.79 | ATAD2 (0.41) | PNPATAD2LMNACYP1A2MAPT | |
| SCHEMBL9960806 | 0.78 | PNP (0.38) | PNPPARP1ABL1RIN1LMNA | |
| SCHEMBL10597939 | 0.77 | PNP (0.33) | PNPPARP1ATAD2LMNACYP1A2 | |
| SCHEMBL1301996 | 0.77 | PNP (0.33) | PNPPARP1 | |
| SCHEMBL7812591 | 0.77 | ABL1 (0.33) | PNPPARP1ABL1RIN1 | |
| SCHEMBL5021633 | 0.76 | PARP1 (0.34) | PNPPARP1ATAD2LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1414822-B1 | IMPROVED SYNTHESIS OF BRANCHED ACYCLIC NUCLEOSIDES | MEDIVIR AB (SE) | 2005-02-16 | — | — | EP | disclosed |
| US-20040147743-A1 | Synthesis of branched acyclic nucleosides | BANK OF NEW YORK, THE | 2004-07-29 | — | — | US | disclosed |
| EP-1414822-A1 | IMPROVED SYNTHESIS OF BRANCHED ACYCLIC NUCLEOSIDES | MEDIVIR AB (SE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003002564-A1 | IMPROVED SYNTHESIS OF BRANCHED ACYCLIC NUCLEOSIDES | MEDIVIR AB (SE) | 2003-01-09 | — | — | WO | disclosed |
| WO-1999030561-A1 | NUCLEOTIDE-BASED PRODRUGS | NEXSTAR PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147743-A1 | Synthesis of branched acyclic nucleosides | SI, POLL, ME1 | PNP 17/4885PARP1 208/4885ABL1 4332/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.