Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6173353 | 0.88 | LMNA (0.45) | LMNAKMT2AALDH1A1 | |
| SCHEMBL6174658 | 0.87 | RXFP1 (0.34) | LMNAIGF1RRXFP1ALDH1A1MAPT | |
| SCHEMBL6170251 | 0.83 | IGF1R (0.33) | LMNAIGF1R | |
| SCHEMBL6172898 | 0.83 | SLC6A9 (0.38) | LMNAKMT2AALDH1A1 | |
| SCHEMBL6175297 | 0.82 | LMNA (0.39) | LMNAIGF1RPTGS2 | |
| SCHEMBL6175175 | 0.82 | IGF1R (0.36) | LMNAIGF1RPTGS2 | |
| SCHEMBL6171994 | 0.81 | ALDH1A1 (0.37) | LMNAIGF1RRXFP1KMT2AALDH1A1 | |
| SCHEMBL6175990 | 0.80 | KIF11 (0.37) | LMNAIGF1RRXFP1 | |
| SCHEMBL6171408 | 0.80 | IGF1R (0.35) | LMNAIGF1RPTGS2 | |
| SCHEMBL6174450 | 0.80 | IGF1R (0.38) | LMNAIGF1RRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1599464-A2 | NOVEL CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | Aventis Pharma S.A. (FR) | 2005-11-30 | — | — | EP | disclosed |
| WO-2004070050-A2 | CYCLIC UREA DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL USE OF SAME AS KINASE INHIBITORS | AVENTIS PHARMA S.A. (FR) | 2004-08-19 | — | — | WO | disclosed |