Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CASR | P41180 | 4/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGDS | O60760 | 1/20 | 0.34 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6986506 | 0.85 | SMN1; SMN2 (0.37) | SMN1; SMN2MAPT | |
| SCHEMBL6976795 | 0.78 | KMT2A (0.47) | SMN1; SMN2HSD17B10GAAMAPT | |
| SCHEMBL6985419 | 0.70 | KMT2A (0.41) | — | |
| SCHEMBL4871373 | 0.70 | SLC6A4 (0.46) | SMN1; SMN2HSD17B10GAAHPGDSCYP2D6 | |
| SCHEMBL6984916 | 0.70 | KMT2A (0.41) | — | |
| SCHEMBL6982440 | 0.69 | PDK1 (0.41) | SMN1; SMN2GAA | |
| SCHEMBL6171559 | 0.67 | ALDH1A1 (0.40) | GAA | |
| SCHEMBL6974917 | 0.66 | KMT2A (0.43) | SMN1; SMN2CASRMAPT | |
| SCHEMBL7297979 | 0.65 | PRKAB2 (0.41) | SMN1; SMN2 | |
| SCHEMBL11500304 | 0.65 | SMN1; SMN2 (0.46) | SMN1; SMN2GAAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1289965-B1 | SUBSTITUTED 1-AMINOALKYL-LACTAMS AND THEIR USE AS MUSCARINIC RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2005-10-26 | — | — | EP | disclosed |