SCHEMBL617974

SCHEMBL617974

COc1cc(C(=O)O)ccc1OCCO

nearest known ligand 0.73

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TSHR P16473 2/20 0.71
▸ CA12 O43570 1/20 0.69
▸ CA1 P00915 1/20 0.69
▸ CA2 P00918 1/20 0.69
▸ CA4 P22748 1/20 0.69
▸ CA6 P23280 1/20 0.69
▸ CA7 P43166 1/20 0.69
▸ TPMT P51580 1/20 0.69
▸ CA9 Q16790 1/20 0.69
▸ CA14 Q9ULX7 1/20 0.69
▸ MRGPRX4 Q96LA9 1/20 0.59
▸ TTR P02766 1/20 0.56
▸ HTT P42858 2/20 0.56
▸ PLA2G4B P0C869 1/20 0.55
▸ PRSS1 P07477 2/20 0.55
▸ MAPT P10636 1/20 0.54
▸ LMNA P02545 1/20 0.54
▸ MAPK1 P28482 1/20 0.54
▸ RAB9A P51151 1/20 0.54
▸ POLB P06746 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30622549 1.00 TSHR (0.71) TSHRCA12CA1CA2CA4
SCHEMBL621879 0.94 CA12 (0.69) TSHRCA12CA1CA2CA4
SCHEMBL30622523 0.92 TSHR (0.69) TSHRCA12CA1CA2CA4
SCHEMBL620892 0.92 TSHR (0.69) TSHRCA12CA1CA2CA4
SCHEMBL19970616 0.92 TSHR (0.69) TSHRCA12CA1CA2CA4
SCHEMBL8085474 0.92 TSHR (0.78) TSHRCA12CA1CA2CA4
SCHEMBL8122418 0.92 TSHR (0.78) TSHRCA12CA1CA2CA4
SCHEMBL19970622 0.91 TSHR (0.68) TSHRCA12CA1CA2CA4
SCHEMBL19970637 0.91 TSHR (0.68) TSHRCA12CA1CA2CA4
SCHEMBL7751323 0.91 TSHR (0.68) TSHRCA12CA1CA2CA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 68 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2603098-B1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER FIRMENICH INCORPORATED (US) 2025-08-06 — — EP disclosed
US-20230416228-A1 AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEWYORK 2023-12-28 — — US disclosed
EP-4217355-A1 AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 Forkhead Biotherapeutics, inc. (US) 2023-08-02 — — EP disclosed
CN-115044022-B Fat and fat-aromatic copolyester capable of being rapidly recycled in closed loop under mild condition, and preparation method, application and recycling method thereof 四川大学 2023-06-06 — — CN disclosed
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. (US) 2022-12-15 — — US disclosed
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS Janssen Biopharma, Inc. (US) 2022-12-15 — — US disclosed
US-20220363640-A1 ANTIVIRAL COMPOUNDS Janssen Biopharma, Inc. (US) 2022-11-17 — — US disclosed
CN-115044022-A Fat and fat-aromatic copolyester capable of being rapidly recycled in closed loop under mild condition, and preparation method, application and recycling method thereof 四川大学 2022-09-13 — — CN disclosed
CN-114716426-A Antiviral compounds 詹森生物制药有限公司 2022-07-08 — — CN disclosed
CN-105636936-B Antiviral compounds 詹森生物制药有限公司 2022-04-05 — — CN disclosed
US-20140128481-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2014-05-08 — — US disclosed
WO-2014031784-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS ALIOS BIOPHARMA, INC. (US) 2014-02-27 — — WO disclosed
WO-2014031784-A1 COMPOUNDS FOR THE TREATMENT OF PARAMOXYVIRUS VIRAL INFECTIONS ALIOS BIOPHARMA, INC. (US) 2014-02-27 — — WO disclosed
US-8592592-B2 Sweet flavor modifier SENOMYX, INC. (US) 2013-11-26 — — US disclosed
EP-2603098-A2 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER Senomyx, Inc. (US) 2013-06-19 — — EP disclosed
EP-2552207-A1 SWEET FLAVOR MODIFIER Senomyx, Inc. (US) 2013-02-06 — — EP disclosed
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 — — US disclosed
WO-2012021837-A2 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER SENOMYX, INC. (US) 2012-02-16 — — WO disclosed
WO-2011123693-A1 SWEET FLAVOR MODIFIER SENOMYX, INC. (US) 2011-10-06 — — WO disclosed
US-20110245353-A1 SWEET FLAVOR MODIFIER SENOMYS, INC. (US) 2011-10-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230416228-A1 AGENTS FOR THE TREATMENT OF DISEASES BY INHIBITION OF FOXO1 FOXO1, FOXO3, GCKR TSHR 1060/4885CA12 4667/4885CA1 4688/4885
US-20220396581-A1 COMPOUNDS FOR THE TREATMENT OF PARAMYXOVIRUS VIRAL INFECTIONS MAVS, SARS1, ZC3HAV1 TSHR 4424/4885CA12 3612/4885CA1 4798/4885
US-20120041078-A1 METHOD OF IMPROVING STABILITY OF SWEET ENHANCER AND COMPOSITION CONTAINING STABILIZED SWEET ENHANCER TFEB, TREH, SLC2A8 TSHR 4370/4885CA12 1128/4885CA1 2518/4885
US-20110245353-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 TSHR 2995/4885CA12 311/4885CA1 862/4885
US-20220363640-A1 ANTIVIRAL COMPOUNDS MAVS, SARS1, ZC3HAV1 TSHR 4469/4885CA12 4108/4885CA1 4791/4885
US-20140128481-A1 SWEET FLAVOR MODIFIER TAS2R5, TAS2R10, TAS2R50 TSHR 2995/4885CA12 311/4885CA1 862/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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