Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.66 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
| ▸ | TYK2 | P29597 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM6B | O15054 | 1/20 | 0.38 |
| ▸ | KDM4A | O75164 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1967163 | 0.83 | TDP1 (0.50) | TDP1SIRT3ROCK2ROCK1TYK2 | |
| Hydrochloric Acid SCHEMBL7274725 | 0.82 | TDP1 (0.48) | TDP1SIRT3ROCK2ROCK1TYK2 | |
| SCHEMBL29571308 | 0.81 | TDP1 (0.68) | TDP1SIRT3KDM4CL3MBTL1KDM4E | |
| SCHEMBL3100795 | 0.81 | TDP1 (0.68) | TDP1SIRT3ROCK2ROCK1TYK2 | |
| SCHEMBL258230 | 0.81 | TDP1 (0.68) | TDP1SIRT3KDM4CL3MBTL1KDM4E | |
| SCHEMBL29496054 | 0.81 | TDP1 (0.68) | TDP1SIRT3ROCK2ROCK1TYK2 | |
| SCHEMBL2265522 | 0.80 | KDM4C (0.47) | TDP1SIRT3ROCK2ROCK1KDM4C | |
| SCHEMBL1265706 | 0.79 | SIRT3 (1.00) | TDP1SIRT3KDM4CL3MBTL1KDM4E | |
| SCHEMBL9504678 | 0.79 | TDP1 (0.66) | TDP1SIRT3KDM4CL3MBTL1KDM4E | |
| SCHEMBL29682389 | 0.79 | SIRT3 (1.00) | TDP1SIRT3KDM4CL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025149628-A1 | PIPERIDINE DERIVATIVES AS INHIBITORS OF NICOTINAMIDE N-METHYL TRANSFERASE | ASTRAZENECA AB (SE) | 2025-07-17 | — | — | WO | disclosed |
| CN-116456985-A | Pyrimidine and pyridine derivatives as HPK1 modulators and methods of use thereof | 深圳市原力生命科学有限公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2022063140-A1 | PYRIMIDINE AND PYRIDINE DERIVATIVES AS HPK1 MODULATOR AND METHODS USING SAME | SHENZHEN IONOVA LIFE SCIENCE CO., LTD. (CN) | 2022-03-31 | — | — | WO | disclosed |
| EP-3719019-B1 | NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2022-01-19 | — | — | EP | disclosed |
| EP-3719019-A1 | NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2020-10-07 | — | — | EP | disclosed |
| EP-3004089-B1 | NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS | HOFFMANN LA ROCHE (CH) | 2020-05-06 | — | — | EP | disclosed |
| CN-105308045-B | New 3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds | 豪夫迈·罗氏有限公司 | 2017-05-17 | — | — | CN | disclosed |
| US-9505742-B2 | 3,4-dihydro-2H-isoquinoline-1-one and 2,3-dihydro-isoindol-1-one compounds | HOFFMANN-LA ROCHE INC. (US) | 2016-11-29 | — | — | US | disclosed |
| EP-3004089-A1 | NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS | F.HOFFMANN-LA ROCHE AG (CH) | 2016-04-13 | — | — | EP | disclosed |
| US-20160075686-A1 | NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2016-03-17 | — | — | US | disclosed |
| US-20130196967-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-08-01 | — | — | US | disclosed |
| US-6914160-B1 | Oxytocin inhibitors | PFIZER INC (US) | 2005-07-05 | — | — | US | disclosed |
| EP-1537085-A1 | OXYTOCIN INHIBITORS | Pfizer Limited (GB) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004020414-A1 | OXYTOCIN INHIBITORS | PFIZER LIMITED (GB) | 2004-03-11 | — | — | WO | disclosed |
| US-6566373-B2 | For therapy of osteoporosis, periodontitis, and arthritis | SMITHKLINE BEECHAM CORPORATION | 2003-05-20 | — | — | US | disclosed |
| EP-1003846-A4 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2002-11-13 | — | — | EP | disclosed |
| US-20020013360-A1 | Protease inhibitors | SMITHKLINE BEECHAM CORPORATION | 2002-01-31 | — | — | US | disclosed |
| EP-1003846-A1 | PROTEASE INHIBITORS | Smithkline Beecham (US) | 2000-05-31 | — | — | EP | disclosed |
| CN-1255161-A | Protease inhibitors | SMITHKINE BEECHAM CORP (US) | 2000-05-31 | — | — | CN | disclosed |
| WO-1998050533-A1 | PROTEASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-11-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020013360-A1 | Protease inhibitors | CTSK, CTSV, CTSS | TDP1 3507/4885SIRT3 1913/4885ROCK2 3245/4885 |
| US-20130196967-A1 | HETEROCYCLIC COMPOUNDS AS INHIBITORS OF LEUKOTRIENE PRODUCTION | LTB4R, LTC4S, LTB4R2 | TDP1 3848/4885SIRT3 2478/4885ROCK2 1934/4885 |
| US-20160075686-A1 | NEW 3,4-DIHYDRO-2H-ISOQUINOLINE-1-ONE AND 2,3-DIHYDRO-ISOINDOL-1-ONE COMPOUNDS | DRD4, DRD3, QDPR | TDP1 1541/4885SIRT3 264/4885ROCK2 614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.