Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PARP1 | P09874 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.36 |
| ▸ | ORAI2 | Q96SN7 | 2/20 | 0.36 |
| ▸ | ORAI3 | Q9BRQ5 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56442 | 0.82 | ORAI1 (0.39) | KMT2AMEN1MAPTGAAGFER | |
| SCHEMBL7040697 | 0.79 | ALDH1A1 (0.42) | KMT2AGAATSHRHSD17B10CYP3A4 | |
| SCHEMBL15514000 | 0.77 | PTPN1 (0.38) | KMT2AMEN1MAPTGAATSHR | |
| SCHEMBL9845992 | 0.74 | MTNR1A (0.37) | KMT2AMEN1MAPTGAATSHR | |
| SCHEMBL918997 | 0.69 | ORAI1 (0.42) | MAPTTSHRHSD17B10POLBCYP3A4 | |
| SCHEMBL3034251 | 0.68 | TSHR (0.36) | KMT2AMEN1MAPTTSHRHSD17B10 | |
| SCHEMBL3646258 | 0.67 | MEN1 (0.52) | KMT2AMEN1MAPTGAAGFER | |
| Biphenyl SCHEMBL8419917 | 0.67 | MEN1 (0.47) | KMT2AMEN1MAPTGAAGFER | |
| SCHEMBL5778129 | 0.67 | KMT2A (0.44) | KMT2AGAATSHRHSD17B10CYP3A4 | |
| Phenylboronic Acid SCHEMBL6701482 | 0.66 | ENPP2 (0.74) | MAPTTSHRHSD17B10POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |