Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 2/20 | 0.45 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 4/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | NGFR | P08138 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 2/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188992 | 0.89 | ALDH1A1 (0.41) | ARALDH1A1MAPTALOX15NGFR | |
| SCHEMBL6188924 | 0.84 | LMNA (0.39) | RORBSMN1; SMN2ALDH1A1MAPTALOX15 | |
| SCHEMBL6187137 | 0.83 | ALDH1A1 (0.45) | KIF11ALDH1A1MAPTGAAPARP1 | |
| SCHEMBL6188757 | 0.79 | RORC (0.42) | RORCMAPTKDR | |
| SCHEMBL6191071 | 0.77 | TUBB1 (0.44) | ALDH1A1MAPTGAAPTGS1PTGS2 | |
| SCHEMBL6187138 | 0.77 | MAOA (0.45) | RORCSMN1; SMN2ALDH1A1 | |
| SCHEMBL6188444 | 0.77 | MAOA (0.43) | RORC | |
| SCHEMBL6185980 | 0.77 | LMNA (0.41) | SMN1; SMN2ALDH1A1MAPTALOX15NGFR | |
| SCHEMBL6186131 | 0.77 | MAOA (0.47) | RORCALDH1A1 | |
| SCHEMBL6187011 | 0.74 | PARP1 (0.42) | ARRORCMAPTPARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |