Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 3/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | RORB | Q92753 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188992 | 0.91 | ALDH1A1 (0.41) | LMNAGAAPOLBMAPTKMT2A | |
| SCHEMBL6185980 | 0.91 | LMNA (0.41) | LMNASMN1; SMN2GAAMAPTHTT | |
| SCHEMBL6185751 | 0.84 | AR (0.45) | SMN1; SMN2GAAMAPTALDH1A1CDK4 | |
| SCHEMBL6189554 | 0.82 | ALDH1A1 (0.46) | LMNAGAAPOLBMAPTMEN1 | |
| SCHEMBL6187433 | 0.79 | MAOB (0.43) | LMNASMN1; SMN2GAAPOLBMAPK7 | |
| SCHEMBL6187153 | 0.77 | MAOB (0.45) | SMN1; SMN2GAAPOLBMAPTNPC1 | |
| SCHEMBL6188627 | 0.77 | MAOB (0.47) | SMN1; SMN2MAPTNPC1RAB9AALDH1A1 | |
| SCHEMBL6191071 | 0.77 | TUBB1 (0.44) | LMNAGAAPOLBMAPTMEN1 | |
| SCHEMBL6186848 | 0.76 | MAOB (0.49) | LMNASMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL6187040 | 0.75 | NGFR (0.42) | LMNASMN1; SMN2GAAPOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |