Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NGFR | P08138 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188924 | 0.91 | LMNA (0.39) | ALDH1A1MAPTGAAALOX15KMT2A | |
| SCHEMBL6185751 | 0.89 | AR (0.45) | ALDH1A1MAPTNGFRGAAPARP1 | |
| SCHEMBL6185980 | 0.84 | LMNA (0.41) | ALDH1A1MAPTNGFRGAAPARP1 | |
| SCHEMBL6191071 | 0.82 | TUBB1 (0.44) | ALDH1A1MAPTGAAPTGS1PTGS2 | |
| SCHEMBL28358993 | 0.78 | NGFR (0.46) | ALDH1A1MAPTNGFRGAAPARP1 | |
| SCHEMBL6184788 | 0.75 | MAOA (0.45) | MAPTGAAKMT2ALMNARAB9A | |
| SCHEMBL6631783 | 0.74 | NGFR (0.43) | ALDH1A1NGFRGAAPARP1CA12 | |
| SCHEMBL6189884 | 0.74 | MAOA (0.48) | ALDH1A1GAANPSR1POLB | |
| SCHEMBL6189592 | 0.74 | MAOA (0.51) | ALDH1A1GAALMNANPSR1POLB | |
| SCHEMBL6189554 | 0.73 | ALDH1A1 (0.46) | ALDH1A1MAPTGAAPARP1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |