Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NGFR | P08138 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6188924 | 0.91 | LMNA (0.39) | LMNARAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL6188992 | 0.84 | ALDH1A1 (0.41) | LMNARAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL6187040 | 0.83 | NGFR (0.42) | LMNARAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL6191071 | 0.82 | TUBB1 (0.44) | LMNARAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL6186570 | 0.80 | ALDH1A1 (0.51) | LMNARAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL28358993 | 0.78 | NGFR (0.46) | LMNARAB9AMAPTALDH1A1MAPK1 | |
| SCHEMBL6185751 | 0.77 | AR (0.45) | MAPTALDH1A1SMN1; SMN2NGFRGAA | |
| SCHEMBL6185825 | 0.77 | TYK2 (0.45) | LMNARAB9AMAPTALDH1A1NPC1 | |
| SCHEMBL6189327 | 0.76 | HPGD (0.46) | LMNAMAPTALDH1A1SMN1; SMN2HTT | |
| SCHEMBL6185706 | 0.75 | MAOB (0.42) | LMNARAB9AMAPTALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554271-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | Rigel Pharmaceuticals, Inc. (US) | 2005-07-20 | — | — | EP | disclosed |
| WO-2004035571-A1 | SUBSTITUTED INDOLES AND THEIR USE AS HCV INHIBITORS | RIGEL PHARMACEUTICALS, INC. (US) | 2004-04-29 | — | — | WO | disclosed |